Peter Stalmans (Leuven, Belgium)


Vitreo macular adhesion can cause significant distortion of the normal macular anatomy, resulting in decreased visual function, and can lead to macular hole formation, or enhance other diseases such as diabetic maculopathy or age related macular degeneration. Release of the vitreo macular adhesion can restore the macular anatomy, and recovery of visual function.


Microplasmin was injected in patients with idiopathic vitreo macular adhesion, macular hole formation or diabetic maculopathy and adherent posterior hyaloids. Foveal anatomy was recorded using SD-OCT at baseline, and at several time-intervals after the injection (1 week, 2 weeks, 1 month, 3 months and 6 months). Detachment of the posterior hyaloid was monitored using B-scan ultrasound.

Effectiveness / Safety:

Release of vitreo macular traction was obtained in a significant percentage of the included cases with vitreo macular adhesion, and closure of several included macular holes. No serious adverse events directly related to the study drug were observed; all adverse events that occurred were graded as “mild”.

Take home message:

Injection of microplasmin can restore the normal macular anatomy in diseases caused by or enhanced by vitreomacular adhesion, with associated restoration of visual function.