To evaluate the long-term outcome of patients suffering from symptomatic polypoidal choroidal vasculopathy (CVP), treated with focal photodynamic therapy (PDT), guided by indocyanine green (ICG).


A prospective study of 11 eyes of 10 patients. Initially treated with focal PDT-VI guided. In 11 eyes the minimum follow up was 12 months, 9 eyes of 24 months, 7 to 36 months, 4 of 48 months and 3 to 60 months. We evaluated the visual acuity (VA) by EDTR. We studied the influence of the number of polyps responsible for alterations, the age of patients or the change of strategy on the final VA. We present the complications of treatment.

Effectiveness / Safety:

The VA was unchanged at 6 months (P = 0.89), 12 months (P = 0.67), 18 months (P = 0.60), 24 months (P = 0.29), 30 months (P = 0.97), 36 months (P = 0.28), 48 months (P = 0.94) and 60 months (P = 0.36). Five (45.4%) eyes remained in regression with a single dose of PDT. Three (27.2%) eyes needed combined treatment with anti-VEGF, laser photocoagulation or both. Complications such as increased exudation of PED (1), neovascular membrane (1) and subretinal hemorrhage (1) were seen. There was no statistically significant correlation between the number of polyps (P> 0.5) or changes in the strategy treatment (P> 0.5) with the final VA. A strong correlation was observed with the age, as older patients required more retreatments (P = 0.07). In conclusion the focal PDT guided by ICG, controls a large number of patients in a long-term period, but not without complications or recurrences. Age remains the greatest predictor.