Familial amyloid polyneuropathy (FAP) is an inherited disorder with autosomal dominant transmission, characterized by systemic extracellular accumulation of amyloid fibrils. The peripheral nervous system and the heart are the main target organs, but the eye may also be involved. The most common type of FAP is related to transthyretin (TTR) and Portugal is an endemic country for FAP TTR Val30Met.TTR is mainly produced by the liver, but a small amount is also synthesized in the eye, in retinal pigment epithelium. Vitreous amyloid opacities usually occur in the late stage of the disease or several years after liver transplantation (LT), although they can be the presenting manifestation of the disease in late onset FAP. When abundant, vitreous amyloid opacities are pathognomonic. Occasionally, peripheral retina may present vascular abnormalities caused by amyloid microangiopathy. The video shows different cases of typical vitreous amyloid opacities and other ocular abnormalities related to FAP.