Authors: Masoud Soheilian, Alireza Ramezani, Ali Tavallali, Mohammad R. Mohebbi, Gholam A. Peyman, Tehran, Iran


Four treatment methods for central retinal vein occlusion (CRVO) were compared with its natural course.


In this partially prospective, comparative, interventional case series on 63 eyes with CRVO, five approaches were compared: intravitreal triamcinolone (IVT) injection (14 eyes), radial optic neurotomy (RON) (13 eyes), combined RON and intraocular triamcinolone injection (RON/IVT) (10 eyes), combined RON, IVT and internal limiting membrane (ILM) peeling,  (ILM peeling/RON/IVT) (12 eyes), and observation (14 cases).

Effectiveness / Safety:

Final visual acuity (VA) in the IVT group was better compared with the observation group (P=0.025), and the RON (P=0.037), RON/IVT (P=0.401), and ILM peeling/RON/IVT (P=0.023) groups. However, after adjustment for baseline VA, the only treatment method with significant VA improvement in relation to observation was RON/IVT (P=0.025, P=0.023, and P=0.054 at months 1, 3, and 6, respectively).

Take home message:

Among five different approaches analyzed in this study, RON/IVT may provide a better visual outcome in the management of CRVO.