To investigate the association of 3-D quantified lesions with best-corrected visual acuity (BCVA) in AMD.


We retrospectively analyzed 65 eyes of 61 typical nAMD patients. Lesions at baseline and month 12 were manually delineated in OCT. Volumes of intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM), and pigment epithelial detachment (PED) were measured.


At baseline, poor baseline BCVA was associated with increased volume of IRF and SHRM and impaired area of ELM. At month 12, poor BCVA was associated with increased volume of IRF, reduced intact ELM area, and decreased EZ area. Baseline BCVA, volume of IRF, and intact area of ELM were significant predictors for BCVA at month 12. Changes of BCVA were associated with changes of SHRM volume, intact EZ area, and ELM area. The predictive power of volumetric analysis was higher than that of qualitative analysis.


BCVA could be explained by 3-D OCT morphology to a fair degree. In addition, 3-D analysis could predict visual outcomes better than qualitative analysis.



Hyung Chan KIM*, Hyewon CHUNG
Konkuk University Medical Center
South Korea
Email : eyekim@kuh.ac.kr
Cell Phone: +821071385657
Work Phone: +82220308198