RETINA PHOTO_Natalia Ferreira

Few conditions are associated to thickening of posterior hyaloid membrane. Familial amyloidotic polyneuropathy (FAP) is characterized by systemic accumulation of mutant amyloigogenic transthyretin in different tissues, the eye included. FAP has peculiar ocular manifestations. Deposition of amyloid in vitreous cavity is a frequent one. Vitreous amyloid deposits (around collagen) are characteristic whitish and cotton or glass wool like opacities. They become pathognomonic with their gradual enlargement in density and extension and are usually related to thickening of posterior hyaloid membrane. Occasionally, small white pinpoint opacities overlying retinal vessels may be present (perivascular amyloid deposits).