Sergienko A., Chichur D.

Advantages:

Rhegmatogenous Retinal Detachment (RRD) has a strong trend towards recurrent course and bilateral lesions. Our investigations have revealed atypical disease course and systemic nature of lesions in patients with complicated RRD course. Goal. Determination of the role of immune mechanisms in development of RRD complicated forms.

Materials & Methods:

We observed 70 patients with unilateral RRD, 80 patients with bilateral RRD, and 60 patients with recurrent RRD course. The control group included 20 healthy persons of the same age. Determination of autoantibodies level to eye structures (pigment-horoidal complex, neuroepithelium, and vitreous body) was carried out in blood serum of a patient, during the reaction of complement use before, after, and at different moments following surgical intervention.

Results:

50% of patients with unilateral RRD, characterized by favorable disease course, showed increased levels of organ-specific autoantibodies (N – up to 10 optical units), which were gradually decreasing, with their complete normalization in the 3rd month after the surgery. Significant increase of autoantibodies level to the mentioned structures, which did not decrease even after a long time (4-12 months) following surgical treatment, was found in 80% of the patients with bilateral RRD and recurrent RRD. Autoantibodies were either not detected or detected within the normal limits in the control group.

Conclusion:

Thus, the results of determining autoantibody level to intraocular structures confirm the presence of autoimmune mechanism in development of complicated RRD forms, and the monitoring of organ-specific antibody level allows tracing the character of the disease course in a given category of patients.