Masood Naseripour, MD (Tehran, Iran), Kamran Manshaee, MD (Tehran, Iran), Pejman Bakhtiari, MD (Tehran, Iran), Shabnam Salimi, MD (Tehran, Iran)

PURPOSE:

To evaluate the role of hyperthermia in control of sufoveal CNV.

METHODS:

Method: the 93 eyes of 85 consecutive patients with angiographically proved CNV underwent TTT with diode laser emission at 810nm. Mean patients age was 74.0 ± 7.1 years (range: 55-88 years). 59 patients (69.4%) were male and 26 (30.6%) were female. 27 patients (29.0%) had hypertension and 10 (10.7%) had diabetes.

RESULTS:

54 eyes with occult CNV, 22 with classic CNV and 17 with mixed type CNV were treated using TTT and followed up for a mean of 11.18 months (range: 6-24 months). 76 CNVs (81.7%) were sub-foveal and 17 (18.3%) were juxta-foveal. Mean CNV area in all 93 eyes was 3.0±1.7DD (range: 0.1 to 7.0 DD). Simple regression showed significant correlation between CNV area and visual acuity in Log MAR scale (Beta=0.239, P=0.021) 32 eyes underwent two sessions of TTT (28 eyes for persistent CNV) and 4 eyes showed recurrent CNV and needed to additional treatment during the study; 6 of 32 eyes had three sessions, all for persistent CNV. Overall mean treatment session was 1.47. Based on CNV type, visual acuity was stabilized (± one line variation) after TTT in 45 eyes (88.2%) of occult group, in 22 eyes (100%) of classic group and in 14 eyes (82.3%) of mixed CNV group. Recurrent CNV occurred in 4 of 93 (4.3%) eyes.

CONCLUSION:

Our study showed that TTT is an inexpensive and efficient method to control of subfoveal CNV with low recurrent rate.