Barbara Parolini – for the Vide Study Group


To better understand the natural history of diabetic macular edema (DME).


Literature review and personal experience on more than 40 patients followed for six months or more without any therapeutic intervention.


DME may show stability or even improvement of visual function and OCT morphology without any ocular therapy, especially if associated with good glycemic control.


DME  is a “fluctuating” condition, tightly related to glycemic control. A correct evaluation of any therapeutic intervention needs to be related to natural history.

Take-home message:

DME may demonstrate natural stability or even natural improvement, sometimes wrongly related to therapeutic intervention.