To evaluate the patients with nonproliferative (NPDR) and proliferative diabetic retinopathy (PDR) with or without macular edema using optical coherence tomography angiography (OCTA).


40 PDR, 54 NPDR and 20 patients with subretinal fluid (SRF) Type 2 diabetic patients enrolled into study. Best corrected visual acuity, anterior segment and fundus examination were done. Diabetic retinopathy was evaluated with fundus florescence angiography (FFA), and OCTA. Pseudophakic patients, patients with history of laser photocoagulation, intravitreal injection excluded from study.Superior foveal, parafoveal vessel density (SFD,SPD), deep foveal, parafoveal density (DFD, DPD), foveal avascular zone (FAZ), acircularity, perimetry, foveal density (FD), flow area of outer retina and choriocapillaries were evaluated with OCTA.


There was no difference between groups in terms of age and gender (p>0,05). Cystoid macular edema (CME) was present in 8 patients (20%) in the PDR group and in 10 patients (18,5%) in the NPDR group. There were PDR in 12 patients (60%) and NPDR in 8 patients (40%) in the SRF group. NPDR and PDR groups were classified as SPD (36,47 ± 8,17 / 41,45 ± 5,17, p = 0,001) and DPD (43,35 ± 5,53 / 46,21 ± 4,96, p = 0,010 ) were found significantly higher in the NPDR group. In patients without macular edema from the groups, SPD (37,44 ± 5,57 / 41,58 ± 5,48, p = 0,002) and DPD (44,28 ± 5,60 / 46,88 ± 4,62; p = 0.030) were significantly higher in the NPDR group. When comparing the presence of CME or SRF in PDR patients, the measurements of DPD (39,62 ± 3,39 / 44,92 ± 5,84; p = 0,044) and FD (39,12 ± 5,79 / 45,00 ± 3,47; p = 0,027) were different. When comparing the presence of CME or SRF in NPDR patients, there was no significant difference between the parameters.


In our study PDR patients had neovascularization and ischemia. The stage of NPDR was moderate-severe. The values of FAZ, perimetry, FD were similar. It is possible to say that neovascularization or ischemia does not cause a change on the flow areas in the choriocapillarys layer. We have found that macular edema, cystoid or subretinal fluid, does not alter the value of the choriocapillary flow area. The patients with SRF has higher FD and DPD than the patients with CME in PDR group.



Adana Training and Research City Hospital
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