Mun Seng Lee, MD (Kota Kinabalu, Malaysia), Mun Toong Lee, MOphth (Kuantan, Malaysia)

PURPOSE:

To evaluate the fundus manifestation among Human Immunodeficiency Virus (HIV) seropositive patients with and without HAART treatment associated with their total CD4 lymphocyte count.

METHODS:

Two hundred and two patients (404 eyes) were recruited in this cross-sectional study. They consisted of consecutive confirmed HIV sero-positive patients with Highly Active Antiretroviral Treatment (HAART) treatment (n=95) or without HAART treatment (n=107), irrespective of age and race, who has attended the Infectious clinic of three general hospital in Klang valley from December 2002 to March 2003.

RESULTS:

In HAART treatment group (N=95), 11 patients (42%) with AIDS group (n=26), 4 patients (33%) with ARC group (n=12) and none of patients (0%) with HIV infected group (n=13) had developed significant fundus lesion. In comparison with the group of CD4 count more than 200 cells/ml, 21 patients had AIDS, 11 patients had ARC and 12 patients had HIV infection. 3 patients (14%) of AIDS group (n=21), 2 patients (18%) of ARC group (n=11) and none of patients (0%) with HIV infected group (n=12) had developed significant fundus lesion. (p<0.005) In NON HAART treatment group (n=107), 5 patients had AIDS, 7 patients had ARC and 52 patients had HIV infection. One patients (20%) with AIDS group (n=5), 2 patients (29%) with ARC group (n=7) and 8 patients (16%) with HIV infected group (n=52) had developed significant fundus lesion (P<0.005).

CONCLUSION:

In short, in the population with AIDS, ARC and HIV infection, the percentages of presence of fundus lesion are higher in patient’s low CD4 count and non-HAART treatment groups.Unfortunately HAART treatment only reduced the percentage in presence of fundus lesion
but will not change the fact that the percentage of presence of fundus lesion is higher in CD4
count less than 200 cells/ml.