Poster Il Han Yun

Purpose:

Hypertension is a major risk factor of retinal vascular occlusion. Generally, blood pressure (BP) has a tendency of fluctuation increased with activity and decreased at night or rest. Especially, non-dipper status is thought to be of clinical and prognostic relevance to target organ damage (TOD) in many studies. So we took part in a measure the 24-hour ambulatory blood pressure monitoring (24hour ABPM) in patients who were diagnosed with branch retinal vein occlusion (BRVO) and did not have any other hypertension history. The purpose of this study was to know the rate of hypertension, aspects of diurnal variation of blood pressure and compare the measurements of clinical BP with that of 24-hour ABPM.

Methods:

The subjects were those who visited the department of ophthalmology from May to October 2012 and diagnosed with BRVO but had not previously had a hypertension diagnosis and related medication intake. The control consisted of patients who did not have previous history of hypertension diagnosis and related medication intake, did not show features of retinal vessel occlusion, and did not have previous history of cardiopulmonary and renal diseases. We defined non-dipper as less than 10% of nocturnal systolic blood pressure fall. Through these methods and values, we compared clinical manifestation, 24-hour ABPM values between the BRVO and control.

Results:

There were 78 patients in the study, the BRVO was composed of 10-male and 28-female, otherwise the control was composed of 20-people each other. In the BRVO and control, 24-hour ABPM results presented a statistically significant difference of 24-hour mean systolic blood pressure (24-hour mSBP) between the two groups. All of 24-hour ABPM values except night mSBP showed statistical difference as compared BRVO group with control group. And ODDs of non-dipper against dipper in the BRVO was 2.25 times more than that in the control. In the BRVO, clinical SBP and DBP didn’t present significant difference between hypertension group and non-hypertension group. By contrast, there were statistically difference for 24-hour mSBP and mDBP depends on hypertension

Conclusions:

In our study, the ratio of diagnosis of hypertension is higher in the BRVO as compared to the control and nocturnal BP of the BRVO is also higher than that of the control. And our study presents some aspects: First, the BRVO have a tendency to maintain high blood pressure at night-time. Secondly, non-dipper can be a risk factor of BRVO, even though the patient didn’t have hypertension. Thirdly, clinical BP measurements don’t reflect diurnal variation of BP for 24 hours. Otherwise, 24-hour ABPM have an effect on management of hypertension as well as diagnosis of hypertension in the BRVO. Finally, we expect that positive management of hypertension with 24-hour ABPM may give rise to better prognosis of BRVO.