Central retinal vein occlusion is a multi-factorial event. Like any venous thrombosis, one of the key components in play is stenosis of the vessel. In the eye, this stenosis generally originates from the vein being compressed by a sclerotic artery in a non-expandable space such as the optic nerve at the level of lamina cribrosa. Resection of the lamina cribrosa should therefore result in proper reperfusion of the central retinal vein and is the inspiring concept behind RON. Timely and proper reperfusion seems the logical fundamental on which to concentrate all subsequent management.

We performed a retrospective study on a group of patients affected by CRVO and were treated with RON and, where needed, with intra-vitreal anti-VEGF. We compared the results with a control group where only anti-VEGF agents had been used to treat the condition.