Murat Karacorlu, MD, Serra Arf Karacorlu, MD, Hakan Ozdemir, MD, Fevzi Senturk, MD – Istanbul Retina Institute, Inc., Istanbul, Turkey

Purpose:

To evaluate the early subretinal fluid changes with optical coherence tomography after photodynamic therapy in patients with age-related macular degeneration.

Methods:

Photodynamic therapy was performed on 12 eyes of 12 patients who presented with subfoveal choroidal neovascularization due to age-related macular degeneration and serial evaluation with optical coherence was performed at 2, 12 and 24 hours after therapy and on the 3rd , 7th, 15th and 30th day.

Results:

In the first 24 hours optical coherence tomography showed an increase in the subretinal fluid in all eyes, and increase in intraretinal fluid in 9 eyes. At the 15th days after therapy reduction of subretinal and intraretinal fluid was observed in almost all eyes.

Conclusion:

Serial optical coherence tomography evaluation of patients with subfoveal choroidal neovascularization due to age-related macular degeneration suggest that the most specific response after photodynamic therapy was the increase in the subretinal fluid.

Take-home message:

The increased subretinal fluid in the early period after PDT might reduce the visual acuity temporarily in the first two weeks.