To evaluate the retinal morphologic characteristics of patients with macropsia caused by epiretinal membrane (ERM) based on spectral-domain optical coherence tomography (SD-OCT).


A cross-sectional non-interventional study was performed to compare the characteristics of retinal structures in eyes with ERM according to the presence or absence of macropsia. Twenty-six patients with ERM and macropsia were defined as the macropsia group and 26 age-matched ERM patients without macropsia were the control group. All participants underwent a full ophthalmologic examination and SD-OCT examination. Macropsia was diagnosed and quantified using a double dot chart (DDC). The thickness of retinal layers, including outer nuclear layer (ONL), and inner segment / outer segment /retinal pigment epithelium (IS/OS/RPE) at the central fovea were measured by electronic calipers of the SD-OCT system. The interocular ratio of each parameter was calculated for each patient and compared between the two groups. The integrity of the external limiting membrane (ELM), inner segment / outer segment (IS/OS) junction and cone outer segment tips (COST) line were evaluated.


The thickness of the IS/OS/RPE differed significantly between both eyes in the macropsia group (p<0.001), whereas the control group was not significantly different (p=0.161). The ONL in the diseased eye was significantly thicker in macropsia group than in control group (p=0.020), whereas these two groups did not differ significantly in the thickness of ONL in the control eye (p=0.860). More patients had a disrupted COST line in the macropsia group (p<0.001 for macropsia group, p=0.252 for control group). No eye showed disrupted ELM and IS/OS junction, regardless of the presence of macropsia.



Sohee JEON, Byungju JUNG, Won Ki LEE
Seoul Saint Mary’s Hospital
Seocho Gu
South Korea
Email: soheeeee@gmail.com
Cell Phone: +811071761357
Work Phone: +811071761357