Short-term Efficacy and Safety Outcomes of Topical Bromfenac on Patients with Diabetic Macular Edema by Han Gyul Yoon, Jong Young Lee, Dong Yoon Kim, Jin Young Kim, South Korea



To determine the efficacy and safety of topical bromfenac on diabetic macular edema (DME) with well-controlled diabetes mellitus.


This retrospective, interventional, case-series included 25 patients with treatment-naïve diabetic macular edema. We included the patients with well-controlled diabetes mellitus showing HbA1c below 8%. We excluded the patients with previous treatment for diabetic macular edema such as intravitreal injection, photocoagulation and with proliferative diabetic retinopathy. We defined DME as a central macular thickness greater than 300um on optical coherence tomography (OCT) scan. All patients received topical bromfenac (bromfenac sodium hydrate 0.9mg/mL eyedrops) treatment in the affected eye twice daily for 2 months. Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline, and at months 1, 2. Outcome data were compared with baseline.


Topical bromfenac was effective on reduction of diabetic macular edema and recovery of visual acuity. Mean CMT were significantly reduced from 367.10 ± 53.59 µm at baseline to 317.60 ± 41.50 µm at 1 month and 305.80 ± 37.94 µm at 2 months (respectively, p=0.037, p=0.007). There were significant improvement of logMAR BCVA from to 0.43 ± 0.29 at baseline to 0.22 ± 0.21 at 1 months and 0.18 ± 0.13 at 2 months (respectively, p=0.007, p=0.004). There was no difference in intraocular pressure. There were no systemic and ocular side effects.


Our results suggest that topical bromfenac had a positive effect in the reduction of diabetic macular edema and recovery of visual acuity with well-controlled diabetic mellitus. Large-scale placebo-controlled trials are needed to establish the effect of topical bromfenac.


Han Gyul Yoon1, Jong Young Lee1, Dong Yoon Kim2, Jin Young Kim1
1 Department of Ophthalmology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea
2 Department of Ophthalmology Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea
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