ABSTRACT

Purpose:

To determine the efficacy and safety of topical bromfenac on diabetic macular edema (DME) with well-controlled diabetes mellitus.

Methods:

This retrospective, interventional, case-series included 25 patients with treatment-naïve diabetic macular edema. We included the patients with well-controlled diabetes mellitus showing HbA1c below 8%. We excluded the patients with previous treatment for diabetic macular edema such as intravitreal injection, photocoagulation and with proliferative diabetic retinopathy. We defined DME as a central macular thickness greater than 300um on optical coherence tomography (OCT) scan. All patients received topical bromfenac (bromfenac sodium hydrate 0.9mg/mL eyedrops) treatment in the affected eye twice daily for 2 months. Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline, and at months 1, 2. Outcome data were compared with baseline.

Results:

Topical bromfenac was effective on reduction of diabetic macular edema and recovery of visual acuity. Mean CMT were significantly reduced from 367.10 ± 53.59 µm at baseline to 317.60 ± 41.50 µm at 1 month and 305.80 ± 37.94 µm at 2 months (respectively, p=0.037, p=0.007). There were significant improvement of logMAR BCVA from to 0.43 ± 0.29 at baseline to 0.22 ± 0.21 at 1 months and 0.18 ± 0.13 at 2 months (respectively, p=0.007, p=0.004). There was no difference in intraocular pressure. There were no systemic and ocular side effects.

Conclusions:

Our results suggest that topical bromfenac had a positive effect in the reduction of diabetic macular edema and recovery of visual acuity with well-controlled diabetic mellitus. Large-scale placebo-controlled trials are needed to establish the effect of topical bromfenac.


CONTACT DETAILS

Han Gyul Yoon1, Jong Young Lee1, Dong Yoon Kim2, Jin Young Kim1
1 Department of Ophthalmology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea
2 Department of Ophthalmology Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea
Email : purenana0719@naver.com
Cell Phone: +821041320719
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