ABSTRACT

Purpose:

To present effects of long-term anti-VEGF (Vascular Endothelial Growth Factor) treatment in eyes after vitrectomy for endophthalmitis in neovascular age related macular degeneration.

Methods:

Core vitrectomy, with intravitreal vancomycin was performed. Spectral domain optical coherence tomography was performed monthly both before and after surgery in the follow- up mode. Anti-VEGF injections were continued after surgery.

Results:

Eight eyes were included in this study. Mean visual acuity was 20/50 Snellen after a mean of 19 intravitreal anti- VEGF injections (p=0.45) one month before endophthalmitis occured. At the first diagnosis of endophthalmitis, mean visual acuity was 20/2000 Snellen. The mean time from first symptoms to surgery was twelve hours (2.5-26 hours). Final mean visual acuity at the end of follow up (12-84 months) was statistically indifferent from visual acuity on the visit just before endophthalmitis (p=0.69). The mean frequency of injections after surgery did not significantly differ from the presurgical scheme of treatment (p=0.97).

Conclusion:

Early vitrectomy for endophthalmitis enables continuation of anti-VEGF injections and does not influence the frequency of injections. This treatment results in satisfactory visual acuity in the long term. Early intervention is safe and might be recommended even for patients with visual acuity better than light perception.


CONTACT DETAILS

 

Zofia MICHALEWSKA*, Karolina BONINSKA, Jerzy NAWROCKI
Ophthalmic Clinic Jasne Blonia
Lodz
Poland
Email : zosia_n@yahoo.com
Cell Phone: +48694251248
Work Phone: +48426368282