Berna Özkan, Hamza Köseoğlu, Levent Karabaş, Turkey

Age related macular degeneration is a complex disease, and its pathophysiology is poorly understood. Proteomic characterization of the protein composition of the vitreous may identify specific biomarkers related to the pathogenesis of exudative age related macular degeneration. In order to identify the possible proteins, the proteome of vitreous samples of 13 exudative age related macular degeneration patients and 11 healthy control subjects wa s analyzed. Panther and String programs were used to determine the biologic relationship and cellular pathways of the identified proteins. According to the proteomic analysis; Alpha 1-acid glycoprotein, Leucine-rich alpha-2-glycoprotein, Alpha-2-HS-glycoprotein, Haptoglobin, Alpha-Crystallin A Chain, Alpha-Crystallin B Chain, Immunoglobulin kappa constant, Beta-crystallin B2, Beta-crystallin A3, Beta-crystallin S levels were down-regulated and Apolipoprotein E levels was up-regulated in patients with exudative age related macular degeneration compared to healthy controls. The biomarker changes specific for the exudative age related macular degeneration could help to understand mechanisms of disease and identify new targets for therapy.

Contact Details:
Berna Ozkan
Acıbadem Mehmet Ali Aydınlar University
Istanbul
Turkey
Cell Phone : +905325493950
Work Phone : +2166494434
Email : drbernaozkan@gmail.com