Quantitative Analysis of Neural Tissues Around the Optic Disc After Panretinal Photocoagulation in Patients with Diabetic Retinopathy


SCIENTIFIC POSTER

Quantitative Analysis of Neural Tissues Around the Optic Disc After Panretinal Photocoagulation in Patients with Diabetic Retinopathy by June Gone Kim, Hyun Seung Yang, South Korea


ABSTRACT

Intoduction:

In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in diabetic patients with or without panretinal photocoagulation, using swept-source optical coherence tomography.

Methods:

We analyzed a total of 206 eyes, comprising 33 normal eyes (Group I), 30 eyes without diabetic retinopathy (Group II), 66 eyes with non-proliferative diabetic retinopathy (Group III), 45 eyes with panretinal photocoagulation (Group IV), and 32 eyes with normal tension glaucoma (Group V). Sequential images acquired using swept-source optical coherence tomography in 3-dimensional mode were used to measure the following variables: the peripapillary retinal nerve fiber layer thickness, neuro-retinal rim thickness, anterior lamina cribrosa depth, prelamina thickness, and lamina cribrosa thickness.

Results:

The peripapillary retinal nerve fiber layer thickness and lamina cribrosa thickness appeared to be thinner in Group IV than in Group III (p = 0.019 and p < 0.001, respectively), although the differences were no more prominent when Group III was compared to Group V (p < 0.001 and p = 0.018, respectively). Multivariate analysis showed that the peripapillary retinal nerve fiber layer thickness was significantly affected by the time of panretinal photocoagulation and by lamina cribrosa thickness (p < 0.001 and p = 0.014, respectively). The result was a negative correlation between the time elapsed after panretinal photocoagulation and the peripapillary retinal nerve fiber layer thickness, rim thickness, and lamina cribrosa thickness (R = -0.765, R = -0.490, and R = -0.419, respectively), but no correlation with the prelamina thickness or anterior lamina cribrosa depth in Group IV.

Conclusion:

Panretinal photocoagulation may alter the peripapillary retinal nerve fiber layer thickness, rim thickness, and lamina cribrosa thickness, but not the prelamina thickness or anterior lamina cribrosa depth. These features are different from the peripapillary features of normal tension glaucoma eyes, in which all variables are affected.


CONTACT DETAILS

June-Gone Kim
Seoul, South Korea
Email : junekim@amc.seoul.kr
Cell Phone: +821090260314
Work Phone: +82230103680