Claudio Azzolini, MD, Matteo Prati, MD, Marco Codenotti, MD, Gisella Maestranzi, MD, Armando D’Angelo, Patrizia Della Valle


To evaluate the efficacy of autologous plasmin enzyme in inducing a posterior vitreous detachment (PVD).


30 eyes of 29 patients (group 1) with different vitreoretinal diseases were considered. All eyes received immediately before vitreoretinal surgery an intravitreal injection of different concentration (from 0.4 to 2 IU) of autologous plasmin enzyme previously prepared by the Coagulation Service. A control group of 20 eyes of 20 patients (group 2) was considered. During surgery, the entity of pharmacological PVD and the peeling easiness were subjectively evaluated. Before surgery, and during the 14 months followup, all patients completed eye examination including optical coherence tomography and fluoroangiography.


The use of autologous plasmin enzyme in vitreoretinal surgery is useful. Surgery is more simple and less traumatic. In some diseases the use of plasmin enzyme allows a better final postoperative visual acuity. The suitable concentration of plasmin enzyme is yet to be defined.