Moderator: Ferenc Kuhn

Monday, June 20, 2005

Optical coherence tomography (OCT) as a screening method for diabetic macular edema

Author: M. Sydorova, R. Skripnik



This study aimed to reveal early macular thickening using optical coherence tomography
(OCT) measurements in diabetic patients.


We investigated 15 eyes from 8 patients with diabetes but no ophthalmoscopic evidence
of retinopathy, 20 eyes from 10 patients with nonproliferative diabetic retinopathy and 14
eyes from 7 healthy volunteers. Retinal thickness was computed automatically from
each tomogram at a total of 600 locations throughout the macula. Macular thickness was
displayed geographically as a false-color topographic map.


Optical coherence tomography was able to quantify the development and resolution of
both foveal and extrafoveal macular thickening. The mean data and standard deviation
foveal thickness was 170 ± 18 microns in normal eyes, 182 ± 17 microns in diabetic eyes
without retinopathy, and 261 ± 114 microns in eyes with nonproliferative diabetic


Significant differences of retinal thickness between patients with diabetic retinopathy and
normals can be detected by OCT even in the absence of clinically significant macular
edema. Significant differences between diabetic patients with and without retinopathy
primary appears in the superior nasal quadrant.

Take-home message:

Central foveal thickness of 200 microns or more should be considered as „edematous“.

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