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Case report:

To report an unexpected resolution of the optic pit maculopathy in a young adult after intravitreal injection of autologous plasmin. Pharmacological vitreolysis, also known as enzymatic vitrectomy utilizing autologous plasmin or microplasmin has been utilized in vitreomacular traction syndromes alone or as a coadjutant during vitrectomy surgery. The injection was performed with autologous plasmin used as an adjunct in the preoperative period with the purpose of weaken the vitreo-macular and vitreo-papillary adhesions in order to facilitate the surgical peeling of the vitreoretinal interface . The Autologous plasmin was prepared utilizing streptokinase as plasmin enzymatic activator. A single intravitreal injection of 0.2 ml of autologous plasmin as made through a 0.22 micron Millipore filter. After the injection there was a gradual absorption of intraretinal and subretinal fluid with a gradual recovery of visual acuity. Visual acuity increased from 20/100 to 20/30, at 7 months follow-up, therefore the planned surgery was suspended.