SCIENTIFIC POSTER 2016_New Lutein-based Dyes vs Standard Synthetic Dyes in Vitreoretinal Interface Surgery

Purpose:

To compare anatomic, functional, microperimetric and electrofunctional outcomes among patients affected by vitreoretinal interface-associated disorders undergoing vitrectomy + epiretinal membrane and/or internal limiting membrane peeling by using new lutein-based dyes or standard synthetic dyes.

Materials and Methods:

This is a randomized perspective comparative study. It was conducted on 30 eyes of 30 patients who underwent vitrectomy via pars plana plus epiretinal membrane and/or internal limiting membrane peeling. They were divided into two groups:

Group 1: 12 patients affected by macular pucker and 3 patients affected by lamellar hole treated with lutein-based dyes,

Group 2: 12 patients affected by macular pucker, 2 patients affected by lamellar hole and 1 patient affected by macular hole treated with standard synthetic dyes.

Best corrected visual acuity (LogMAR), retinal sensitivity (dB), electroretinographic response recorded in ring 1, anatomic outcomes in terms of central subfield thickness (µm) and average RNFL thickness (µm), were recorded preoperatively, 15 days and 1 month postoperatively.

Results:

All parameters were recorded and compared to each other form baseline to the 15th day postoperatively, from baseline to 1 month postoperatively and from the 15th day to 1 month postoperatively. There were no statistically significant differences between the two groups, 1 and 2, in terms of anatomic, functional, microperimetric and electrofunctional parameters estimated during the follow up. Patients from both groups had major improvements 1 month after surgery.

Conclusion:

Vitrectomy via pars plana plus epiretinal membrane and/or internal limiting membrane peeling with the use of standard synthetic dyes or of new lutein-based dyes are techniques equally safe and effective. These techniques showed anatomical and functional success 1 month postoperatively.