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With either diabetic macular edema or with proliferative retinopathy we should ascertain that all retinal laser treatment needed has been done and above all emphasize the importance of a good metabolic control to achieve good results. We certainly should not give up and use anti-angiogenic or corticosteroid intra-vitreal injections as much as needed to control neovascularization or macular edema, sometimes with good and relatively stable results. I will show statistics and examples of some particular patients within this diabetic retinopathy subgroup.