Alarcón Valero Isaac, Vilaplana i Blanch Daniel, Poposky Vladimir, Martínez-Giralt Olga, Berniell Trota José Antonio, Acebes Roldán Xènia, Castilla Céspedes Miguel

Purpose:

Analyse the usefulness of antioxidant drug supplementation using multifocal electroretinogram (mf-ERG) in normal and dry AMD eyes.

Methods:

48 eyes, all have had cataract surgery and with a visual acuity of 20/40 or better. Two groups: cases (24 eyes), (dry-AMD) and controls (24 eyes), (normal fundus). In each group we randomize which eyes receive antioxidant drug supplementation. All the eyes had an initial and final exam (6 months later) including: visual acuity(ETDRS), biomicroscopy, fundus examination, retinography and mf-ERG.

Effectiveness / Safety:

We analysed the central ring of mf-ERG. Comparing treated eyes versus non-treated eyes, ignoring if they are cases or controls, we find statistically significant differences in width and density of P1 wave and scalar product. In cases we do not find significant differences between treated and non-treated eyes. In controls, we find statistically significant differences in width and density of P1 wave in treated eyes, and no differences were found in non-treated eyes. Discussion: The antioxidant drug supplementation improves the macular function measuring it with mf-ERG, but a larger study should be performed in order to find if it is useful in patients with dry AMD.