ABSTRACT

Aim:

The aim of the study was to evaluate the morphologic changes of the macula after three initial loading injections of ranibizumab or aflibercept in patients with wet form of AMD.

File & Methodology:

In the retrospective study we evaluated 148 patients (97 women, 51 men). 74 patients (46 women, 28 men) were treated with aflibercept and 74 patients (51 women, 23 men) were treated with ranibizumab. Using optical coherence tomography we evaluated the disappearance of 3 morphological signs – serous retinal pigment epithelium detachment, subretinal fluid, and intraretinal cysts. The statistical significance of the results was calculated with the McNemar test (alpha = 0.05) and Fisher test (alpha = 0.05).

Results:

The complete disapearance of the serous retinal pigment epithelium detachment we observed only in 7,94% patients of the aflibercept group and in 4,05% patients of the ranibizumab group. We observed the complete resorbtion of the subretinal fluid in 47,46% resp. 37,50% patients of the aflibercept resp. ranibizumab group (p<0,001). The complete resorbtion of the intraretinal cysts was observed in 55,55% resp. 51,28% patients of the aflibercept resp. ranibizumab group (p<0,001).

Conclusion:

Both drugs statistically significantly reduce the occurrence of the intraretinal cysts and subretinal fluid (p <0.001) in patients with wet form of AMD. There is noticeably weaker the influence of both these drugs on the serous retinal pigment epithelium detachment in the patients with wet form of AMD.


CONTACT DETAILS

Oldřich Chrapek1, Jiří Jarkovský2, Petr Kolář3, Pavel Nemec4, Jan Studnička5,  Barbora Chrapková1
1 Department of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University Olomouc, I. P. Pavlova 6, 775 20, Czech Republic
2 Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University, Brno, Kamenice 126/3, 625 00, Czech Republic
3 Department of Ophthalmology, University Hospital, Brno, Jihlavská 340/20, 625 00, Czech Republic
4 Department of Ophthalmology, The Military University Hospital Prague, At Military Hospital 1200, 169 02, Czech Republic
5 Department of Ophthalmology, Faculty of Medicine in Hradec Králové, Charles University in Prague and University Hospital in Hradec Králové, Sokolská 581, 500 03, Czech Republic