Medical Therapy for Bilateral Uveal Effusion Syndrome in Nanophthalmos


Medical Therapy for Bilateral Uveal Effusion Syndrome in Nanophthalmos by Sang-Yoon Lee, Joong Hyun Park, Eun Kyoung Lee, South Korea



Surgical management has been employed for the treatment of uveal effusion syndrome (UES), but the procedure is invasive and the response to surgery is variable. Herein, we report a case of bilateral UES in a patient with nanophthalmos treated successfully with non-surgical management.

Case Presentation:

A 64-year-old man visited the clinic with a complaint of decreased visual acuity in both eyes. Fundus examination revealed macular edema with serous retinal detachment in both eyes. His axial lengths were 18.53 mm and 18.37 mm in the right and left eyes, respectively. Ultrasonography revealed a grossly thickened sclera in both the eyes. Surgical procedures were considered under the diagnosis of nanophthalmos with uveal effusion. However, because of his terminal colon cancer, we decided to manage the patient conservatively. Topical latanoprost (0.005% twice a day) and oral acetazolamide (250 mg twice a day) were administered. Two weeks later, macular edema decreased and subretinal fluid accumulation resolved in both the eyes. We withdrew acetazolamide because of nausea and vomiting, and added topical bromfenac (0.1% twice a day). After 2 months of treatment, further improvement of macular edema was noted. The patient has shown no evidence of recurrence during the 6 months following treatment.


Resolution of chorioretinal detachment in UES, despite scleral abnormality, could be obtained with medical therapy alone. Conservative therapy can be of value in the treatment of UES prior to invasive surgical treatment.



Sang-Yoon Lee
Jeju, South Korea
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