RVO

358 cases of edema exceeding 300 microns following CRVO were submitted by 51 retina specialists. 111 were treated by anti-VEGF and 80 by vitrectomy and ILM peeling but other treatments were also chosen. The initial VA were not comparable. We can notice that eyes treated by Ozurdex have a much higher initial VA and eyes treated by triamcinolone have a much lower one. However the standard deviations (the dispersion of the data) are similar.

When focusing now on each individual major pure treatment, ie excluding combined treatments, we can note that:– Triamcinolone does not result in improvement,– Ozurdex, with a mean number of 2 injections seems to be comparable to antiVEGF, after 8 injections, but the number of cases and the follow-up with Ozurdex are not sufficient– ILM peeling seems to be the most effective treatment, giving to the patient a final vision 2 to 3 times higher than with the other treatments.

When focusing now on each individual major pure treatment, we can see that Ozurdex is not very exciting as its effect decreases with the time. The improvement obtained by anti-VEGF seems better even if the curve seems to decrease after some injections. Here again, the most interesting rising curve is the ILM peeling one with a final vision twice as high as the one obtained by the anti-VEGF.

The number of cases improving 3 or more lines is much higher after ILM peeling than after anti-VEGF. This is statistically significant. Same thing applies to cases obtaining 6 lines or better. However, this classical way of presentation is not very meaningful since the improvement is dependent on the pre-treatment VA.

Much more accurate could be this way of presentation where the improvements can be compared taking into consideration the initial VA.according to that we can declare that the gold medal has to be awarded to PPV + ILM with a medium improvement twice as high as the one obtained by the anti-VEGF which achieves the silver medal.