Finally …

A reduction of macular thickness is achieved with all treatments. The maximum reduction is obtained after 9 to 12 months. Then the thickness of the retina seems to stabilize when anti-VEGF and ILM peeling are used. When Triamcinolone is used alone or in combination, the retinal thickness seems to increase again after one year.

In order to understand this phenomenon, we tried to analyze the difference between pre and post treatment macular thickness using box plots. This technique allows us to analyze a population by grouping 50% of the population in the box (separated in 2 by the median) and adding an indication of the upper and the lower desile between which 80% of the population is represented.

When considering the risk of development of atrophy, we see that all the groups, except the ILM peeling group, have at least 10% of their population with a thickness smaller than 180 microns. This can explain that a higher decrease in macular thickness is not necessarily linked with a better improvement.