Perfluorocarbon (PFC) liquid is a widely used intraoperative surgical tool for the management of various vitreoretinal conditions. Retained subretinal PFC is a known complication that was observed to occur at a higher frequency with the use of small gauge vitrectomy. Most recently published literature focused on the various techniques for removal of subretinal PFC. In our case series, we report the longterm outcomes of retained subretinal PFC in 4 eyes. Different patterns of outcome were observed, including formation of subretinal fibrosis, inferior migration of PFC globule and macula hole formation. Serial fundus photos and optical coherence tomography findings obtained over a 12-month observational period are presented.