Siamak Moradian, Amir Faramarz, Qiumars Heidari, Masoud Salehipoor, Mohammad Mohammadzadeh (Tehran, Iran)

Advantages:

To compare the results of IVT vs IVB vs sham injections at the end of phacoemulsification (PE) on diabetic macular edema (DME).

Methods:

In a RCT 88 diabetic patients with at least moderate NPDR were undergone one of the 3 injections, IVT (4 mg), IVB (1.25 mg) or sham at the end of PE. Patients were followed 1, 3, 6 and 12 months after. Main outcome measures were changing in BCVA and CMT during FU examinations.

Effectiveness / Safety:

Only in IVB group there are statistically significant improvements of BCVA at 1 (p = 0.043) and 3 (p = 0.034) months relative to the sham group. None of the changes in CMT between groups were statistically significant.

Take home message:

IVB injection at the end of PE in patients with at least moderate NPDR results to further visual improvement until 3 months after PE.