In central serous chorioretinopathy (CSC), we evaluated the optical coherence tomography (OCT) images of the retinal pigment epithelium (RPE) obtained by scanning in an “en-face” direction (parallel to the retinal surface), and compared them, firstly, with the morphological findings in the unaffected eyes and secondly, with the leakage points on fluorescein angiography (FA).


In prospective study 42 eyes of 21 patients with unilateral acute CSC were examined with Cirrus HD-OCT (Macular Cube-Advanced Visualization-RPE Slab). CSC was confirmed in 21 eyes (group A) and the contralateral 21 asymptomatic eyes formed the control group B.  Complete ocular examination was performed and FA was obtained in all patients at the same day. The differences in visual acuity, central macular thickness and the major demographics were also recorded.

Effectiveness / Safety:

“En-face” OCT images showed irregular RPE patterns: group A: 100%; group B: 9,5% (2/21) – 90,5% of specificity. The analyzed results agreed with the fluorescein dye leakage location on FA in 18 of 21 studied eyes – 85,7% of sensitivity.

Take home message:

In eyes with acute CSC, in contrast with conventional longitudinal OCT scans, the extent of the disease could be visualized more accurately by providing the “en-face” map at RPE level. High correlation compatibility between the “en-face” OCT findings and the FA images was demonstrated by typical hyporeflective morphologic changes at the point of dye leakage.