Kubilhan Elmas, Özgür Bilen, Ali Altýnsoy (Ankara, Turkey)


To describe the efficacy of intravitreal bevacizumab (Avastin) in patients with cystoid macular edema (CME) after cataract surgery (Irvine-Gass syndrome).


This retrospective case series comprised 8 eyes of 8 patients with CME after cataract surgery refractory to current standard treatment that received an injection of 1.25 mg intravitreal Avastin. The main outcome measures were visual acuity, retinal thickness on optical coherence tomography (OCT), and complications related to treatment.


The median duration of CME before treatment with intravitreal Avastin was 17 weeks (range 1 to 45 weeks). Although the mean retinal thickness decreased slightly after intravitreal Avastin, the mean visual acuity remained unchanged. There were no adverse effects of the intravitreal injections.


Intravitreal injection of Avastin, although safe, did not result in improved visual function in patients with postoperative CME. In contrast to findings in a previous case report, the beneficial effect of vascular endothelial growth factor inhibition in Irvine-Gass syndrome was not observed.