Woohyok Chang_SCIENTIFIC POSTER 2015_2


To investigate efficacy of intravitreal aflibercept injection in patients with treatment-naive polypoidal choroidal vasculopathy (PCV).


A prospective, multi-center, single-arm, interventional case series conducted in South Korea. Forty seven patients with polypoidal choroidal vasculopathy (PCV) confirmed using indocyanine green (ICG) angiography were enrolled. Aflibercept (2.0 mg) was injected every month three times and then every two months. Visual acuity measurement and optical coherence tomography were performed every visit. Fluorescein and ICG angiography were obtained at baseline and month 3.


After 3 loading doses of aflibercept, visual acuity improved significantly from 53.7 at baseline to 62.8 letters at month 3 (p<0.01). On ICG angiography, complete polyp regression was seen in 25 eyes (55.3%), partial regression in 15 eyes (31.9%), and no change in 6 eyes (12.8%). At 6 months, visual acuity maintained to 63.8 letters.


Aflibercept intravitreal injections showed favorable outcomes for PCV at month 6.

Contact Details:

Email: changwh@ynu.ac.kr
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