Yoon Hyung Kwon_SCIENTIFIC POSTER 2015

Purpose:

To investigate the effect of topical pranoprofen 0.1% in the treatment of acute serous chorioretinopathy.

Methods:

This was a retrospective review of 52 serous chorioretinopathy cases (52 patients). 26 patients were received topical pranoprofen 0.1% (treatment group); and the other 26 patients did not receive any treatment served as the control group. Baseline and follow-up visual acuity (LogMAR), subfoveal choroidal thickness, subretinal fluid and central macular thickness were reported and compared in two groups.

Results:

In the treatment group mean subfoveal choroidal thickness was 366 μm at baseline and significantly improved to 289 μm at 6 months (p=0.005). Subretinal fluid height and central macular thickness also significantly improved from 188m, 375m at baseline to 98m, 270m after 1 month (p=0.002, p=0.003). In the control group, subfoveal choroidal thickness decreased throughout the follow-up period but it was not a meaningful decline. There was a significant difference in mean subretinal fluid at 6 months, central macular thickness at 3 months compared to the baseline in the control group. Improvement of visual acuity was observed in both groups 6 months after treatment but no significant improvement was found in the control group. However, 0.1% pranoprofen treatment group (p=0.002) had significant visual acuity improvement compared with their baseline values. The recurrent rate in 0.1% pranoprofen treatment group was lower than control group (23% vs 38%) but there were no statistically significant differences (p=0.229, chi-square test).

Conclusion:

We found that topical pranoprofen 0.1% therapy was effective in treating acute CSC, leading to visual improvement, resorption of subretinal fluid, decreasing the subfoveal choroidal thickness and central macular thickness. Topical pranoprofen 0.1% has a beneficial therapeutic effect in acute CSC patients compared to the observation group.

Contact Details:

Email: yhkwon@dau.ac.kr
Cell Phone: +821028492902