Advantage:

To determine the frequency and characteristic features of new- onset neovascularization (CNV) in age related macular degeneration (AMD) with spectral domain optical coherence tomography (SD-OCT).

Methods:

Prospective, observational study of 68 patients with unilateral CNV treated with Bevacizumab. SD-OCT and visual acuity (logMAR) was measured at baseline and then monthly in both, the Bevacizumab treated eye and in the study eye. Inclusion criteria for the study eye were: the absence of CNV at baseline, absence of geographic atrophy in the fovea and the presence of at least one druse.

Effectiveness:

During the observation time new onset CNV was observed in 26 eyes. Type 1 CNV was observed in 7 eyes, type 2 CNV was observed in 11 eyes, mixed type 1 and 2 CNV in 3 eyes and type 3 CNV was detected in 4 eyes. Several morphologic features characterize SD-OCT images one or more months before new onset of CNV. Among those: new retinal pigment epithelium defects, new photoreceptor defects, drusen touching the photoreceptor layer and the external limiting membrane, hyperreflective spots probably representing new growing vessels.