To determine the frequency and characteristic features of new- onset neovascularization (CNV) in age related macular degeneration (AMD) with spectral domain optical coherence tomography (SD-OCT).


Prospective, observational study of 68 patients with unilateral CNV treated with Bevacizumab. SD-OCT and visual acuity (logMAR) was measured at baseline and then monthly in both, the Bevacizumab treated eye and in the study eye. Inclusion criteria for the study eye were: the absence of CNV at baseline, absence of geographic atrophy in the fovea and the presence of at least one druse.


During the observation time new onset CNV was observed in 26 eyes. Type 1 CNV was observed in 7 eyes, type 2 CNV was observed in 11 eyes, mixed type 1 and 2 CNV in 3 eyes and type 3 CNV was detected in 4 eyes. Several morphologic features characterize SD-OCT images one or more months before new onset of CNV. Among those: new retinal pigment epithelium defects, new photoreceptor defects, drusen touching the photoreceptor layer and the external limiting membrane, hyperreflective spots probably representing new growing vessels.