SCIENTIFIC POSTER 2016_Detection of choroidal neovascularization using Optical Coherence Tomography Angiography compared to Traditional Angiography in Exudative Age-Related Macular Degeneration

Purpose:

To determine the sensitivity and specificity of optical coherence tomography angiography (OCTA) in detecting choroidal neovasculararization (CNV) compared to fluorescein angiography (FA) considered as the first choice technique.

Methods:

A retrospective observational study. In the period between June and October 2015, 45 patients underwent same-day fluorescein angiography (FA) with or without indocyanine green angiography (ICGA), for suspected neovascular AMD; all participants were also evaluated with OCT Angiography, AngioVue system (Optovue, Inc) the same day. All images obtained from FA, ICGA and OCTA, were evaluated by two masked ophthalmologists independently. FA used for the detection of CNV was considered as the reference standard.

Results:

Concordance between different imaging modalities resulted good: FA and OCTA was 0,62 (0,61-0,80) and between FA/ICGA and OCTA was 0,76 (0,61-0,80). Considering only CNV with occult component, concordance resulted moderate: 0,43 (0,41-0,60) for FA and OCTA, 0,63 (0,61-0,80) for FA/ICGA and OCTA. The sensitivity for detecting CNV was: 92% for FA and OCTA (95% confidence interval [CI], 0,75-0,98), 83% for FA/ICGA and OCTA (95% CI, 0,65-0,89). Sensitivity for detection of CNV in cases with no classic component was 80% for FA and OCTA (95% CI, 0,49-0,94) and 73% for FA/ICGA and OCTA (95% CI, 0,48-0,83). Specificity of FA and OCTA was higher (25%) than that of FA/ICGA and OCTA in all cases.

Conclusions:

OCT angiography shows good concordance compared to traditional FA with or not ICGA. OCTA and FA show high sensitivity in all cases with or no occult component. Sensitivity   results lower if ICGA is considered in the comparison analysis because of the presence of occult lesions with hemorrhagic component. Specificity resulted very low in all groups.