To investigate the correlation between the area of fluorescein leakage and central foveal thickness (CFT) in common causes of macular edema with visual acuity (VA).


A consecutive series of 111 eyes (71 patients) with macular edema was included. The study had 3 different groups: Group I (71 eyes) with diabetic macular edema, group II (29 eyes) with edema secondary to vein occlusion and group III (11 eyes) with pseudophakic macular edema. The maximum area of leakage of fluorescein dye was measured using the software of the Imagenet system. Retinal thickness and tomographic patterns were obtained by OCT. Angiographic and tomographic findings were correlated with VA.


There was no significant difference between patient age and gender in the studied 3 groups. VA was statistically higher in group II compared to group I and III. Despite that area of leakage was relatively higher in group I, there was no statistically significant difference between area of leakage in the three groups. Statistically significant difference was found in CFT in group I and II. An inverse statistically significant correlation was found between VA and CFT in group I and III. VA correlated inversely with area of leakage in group I only. There is a weak negative but significant correlation between VA and both CFT and area of leakage in group I. There is an inverse weak non-significant correlation and both of them in Group II. There is a moderate negative significant correlation between VA and CFT in group III but inverse weak non-significant correlation between VA and area of leakage.


CFT and area of leakage correlate with VA acuity in cases of diabetic retinopathy. CFT correlates with VA in cases of pseudophakic macular edema. Other factors also contribute to presenting visual acuity of the patients. Further studies on larger groups are recommended.

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