SCIENTIFIC POSTER

Comparison of Combined Low Dose Bevacizumab-Triamcinolone and Bevacizumab Alone Intravitreal Injection in Branch Retinal Vein Occlusion by Min Ho Shin, Young Je Choi, South Korea


ABSTRACT

Purpose:

To report the effects of combined low dose bevacizumab and low dose triamcinolone intravitreal injection compared with bevacizumab intravitreal injection in patients with macular edema due to branch retinal vein occlusion.

Methods:

In total, 30 eyes of 30 patients diagnosed with macular edema due to branch retinal vein occlusion were evaluated. Group A (15 eyes of 15 patients) was treated with intravitreal injection of combined low dose bevacizumab (0.625 mg/0.025 mL) and low dose triamcinolone (1 mg/0.025 mL). Group B (15 eyes of 15 patients) was treated with intravitreal injection of bevacizumab (1.25 mg/0.05mL). The best corrected visual acuity (BCVA), central macular thickness (CMT) and intraocular pressure (IOP) of treated eyes were measured before injection and at 1 month, 2 months, 3 months after injection.

Results:

The baseline characteristics were no significant difference between both groups. In combined bevacizumab and triamcinolone injection group BCVA increased significantly at 1 month, 2 months and 3 months after injection (p<0.05). On the other hand, in the bevacizumab alone injection group BCVA increased significantly only at 3 months after injection (p<0.05). In both groups CMT decreased significantly at 1 month, 2 months and 3 months after injection (p<0.05). In combined injection group IOP showed significant increase at 2 months after injection (p>0.05), but bevacizumab alone injection group showed no significant change. The BCVA, CMT and IOP after injection showed no significant differences between combined injection group and bevacizumab alone injection group(p>0.05). Significant complications associated with intravitreal injection were none.

Conclusions:

In both groups BCVA and CMT improved significantly 3 months after injection. While, combined group showed more significant improvement of BCVA in earlier phase after injection. The combination of low dose bevacizumab and low dose triamcinolone intravitreal injection maybe useful and safe for the treatment of macular edema due to branch retinal vein occlusion.


CONTACT DETAILS

Min Ho Shin, Young Je Choi
Gyeongsang National University, Department of Ophthalmology
Jinju
South Korea
Email : god1048576@naver.com
Cell Phone: +821046028088
Work Phone: +82557508171