Poster 1 Salim Ben Yahia


To compare the effect of topical diclofenac and topical dexamethasone on blood-aqueous barrier breakdown following posterior segment surgery.


The study included 50 eyes treated with posterior segment surgery for rhegmatogenous retinal detachment, intravitreal haemorrhage, epiretinal membrane, or macular hole. Patients underwent scleral buckling, pneumatic retinopexy, or pars plana vitrectomy with either silicone oil or gas tamponade. Patients were divided into 2 groups (25 eyes each group) treated with topical diclofenac sodium 0.1% three times daily for 28 days, and dexamethasone acetate 0.1% three times daily for 28 days. The inflammatory reaction in the anterior chamber was measured with laser flare photometry preoperatively and 1, 7, 14, 28, and 90 days postoperatively.

Effectiveness / Safety:

There was no significant difference between the two groups regarding mean aqueous flare at day 0 (p=0.77), day 1 (p=0.17), day 7 (p=0.77), day 14 (p=0.6), day 28 (p=0.98), and day 90 (p=0.35). Diclofenac sodium seems to be as potent as dexamethasone phosphate, as good as anti-inflammatory agent, and may replace corticosteroid therapy after posterior segment surgery.