SCIENTIFIC POSTER

Comparative Analysis of Long-term Visual Outcomes by Young Joo Park, Kwan Hyuk Cho, Se Joon Woo, Kyu Hyung Park, South Korea


ABSTRACT

Purpose:

To compare clinical characteristics and long-term visual outcome in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nvAMD).

Method:

The medical records of patients diagnosed with PCV and nvAMD at Seoul National University Bundang Hospital from May 2003 to May 2014 were reviewed retrospectively. Basic clinical characteristics including age, sex, and underlying diseases and annual changes in best-corrected visual acuity (BCVA) of the diseased eye for the whole followup period were collected. BCVA changes of the PCV and nvAMD group were compared, adjusting sex, age and initial visual acuity. In the PCV group, visual outcomes were compared by BCVAs between different treatment strategies.

Result:

161 eyes of 146 patients with PCV and 475 eyes of 416 patients were included. Mean follow-up period of total patients was 4.78±2.47 year. Onset age were younger in the PCV group than in the nvAMD group (67.0±8.0 vs 71.3±7.97, P<.001). BCVA was better in the PCV group than the nvAMD group at the initial visit (0.56±0.51 vs 0.78±0.60, P<.001) and at the final visit (0.69±0.71 vs 1.01±0.76, P<.001). PCV group showed better visual acuities than those of nvAMD group throughout the entire follow-up periods with sex, age and initial visual acuity adjustment (all P<.001 for 10 years). In PCV group, treatment strategy have largely changed from ‘PDT only’ to ‘anti-VEGF injection’ or ‘PDT combined with anti-VEGF injection’ since 2006 (100% ‘PDT only’ in 2003 vs 66% ‘anti-VEGF injection’ and 66.77% ‘PDT combined with anti-VEGF injection’ in 2015) but the visual acuity improvements among the different treatment groups did not significantly differ.

Conclusion:

Visual acuity gradually deteriorated in the PCV and nvAMD group, but the PCV group showed better visual acuity than the nvAMD group throughout the long follow-up periods. Treatment strategy for PCV varied for years, but the visual gain did not significantly differ according to the different strategies.


CONTACT DETAILS

Young Joo Park, Kwan Hyuk Cho, Se Joon Woo, Kyu Hyung Park
Seoul National University Bundang Hospital
Seongnam
South Korea
Email : esther.youngjoo.park@gmail.com
Cell Phone: +821089920106
Work Phone: +82317876884