ABSTRACT

Purpose:

To analyze features of the choriocapillaris (CC) in eyes with pachychoroid pigment epitheliopathy (PPE), using optical coherence tomographic angiography (OCTA).

Method:

A prospective cross-sectional study. Forty-six eyes of 31 patients with PPE, 32 age-matched normal pachychoroid eyes, and 30 age-matched normal controls were included. Macular 3x3mm angiographic images were obtained with swept-source OCTA. Vascular density and flow reduction area in the CC were analyzed. Topographical correlation of CC flow impairment with the epitheliopathy lesion and the dilated choroidal large vessel (pachyvessel) was also assessed.

Results:

CC vascular density was significantly lower in eyes with PPE compared to normal pachychoroid and controls (P = 0.019 and 0.005, respectively). The total number of flow voids in the CC and the total and average flow void area was the highest in PPE followed by normal pachychoroid and then controls (163.5 vs 139.5 vs. 114.9, P = 0.002; 0.702 vs. 0.460 vs. 0.332 mm2, P = 0.009; 0.041 vs. 0.033 vs. 0.028 mm2, P = 0.011, respectively). Flow void areas were colocalized with all epitheliopathy lesions and 87.9% flow void areas were found over the areas of the pachyvessel.

Conclusion:

The area of flow deficit in the CC is increased in eyes with PPE and its presence was associated with the epitheliopathy lesion and the pachyvessel underneath.


CONTACT DETAILS

 

Jiwon BAEK, Won Ki LEE
Bucheon St.Mary’s Hospital, The Catholic University of Korea
Bucheon
South Korea
Email : md.jiwon@gmail.com
Cell Phone: +8201051371087
Work Phone: +8201051371087