Changes in Cytokine Concentrations Before and After Intravitreal Injection of Bevacizumab in Patients with Chronic Central Serous Choroidopathy by Dae Young Lee, Yu Jung Kim, Dong Heun Nam, South Korea



The purpose of this study was to investigate the change in the intraocular aqueous cytokine concentration following intravitreal bevacizumab injection in Chronic Central Serous Chorioretinopathy (CSC), and to identify the relevance to the treatment effects.


12 eyes of 12 patients with chronic central serous chorioretinopathy and 6 eyes of 6 patients undergoing cataract surgery participated in this study. Aqueous humor samples were obtained before and 4 weeks after the intravitreal injection in the chronic CSC group and before the surgery in the control group. Aqueous concentrations of interleukin (IL)-6, IL-8, interferon-induced protein (IP)-10, monocyte chemotactic protein (MCP)-1, platelet-derived growth factor (PDGF)-AA, and vascular endothelial growth factor (VEGF) were measured by multiplex bead assay. we also investigated whether the changes in the intraocular cytokine concentrations affected visual acuity and central foveal thickness(CFT) by the Optical Coherence Tomography (OCT).


The cytokine levels of IL-6, IL-8, PDGF-AA and MCP-1 in the chonic CSC group were significantly lower than those of the control group ( p=<0.01, 0.049, <0.01 and 0.031 respectively). In the chronic CSC groups, the comparison of cytokine changes after intravitreal bevacizumab injection showed a significant increase in IL-8 levels (p=0.046), but a significant decreases in VEGF levels (p=<0.01). The levels of IL-6, IP-10, PDGF-AA and MCP-1 were not significantly different after injection. After injection, the greater the range of the changed VEGF, the greater the increase in CFT reduction rate.


Intravitreal bevacizumab injection reduces VEGF and increase IL-8 of plural cytokine profiles in the eyes of patients with chronic CSC, which might explain the choroidal ischemia involved in the pathogenesis of CSC.



Dae Young Lee, Yu Jung Kim, Dong Heun Nam
Gachon University Gil Hospital
South Korea
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