To evaluation of microvasular change(microaneurysm) in diabetic retinopathy patients who undergo intravitreal bevacizumab injection by FAG(fluorescein angiography).


Thirty- one eyes of 31 diabetic retinopathy patients undergoing intravitreal bevacizumab injection(1.25mg/0.05ml) only one eye were included in this study. The control group(31 eyes) were the opposite eyes. We made an exception for both intravitreal bevacizumab injection and medial opacity which obscured fundus image by vitreous hemorrhage. The microaneurysmal change was analyzed at same site that is the circle with a radius of optic disc and macular by FAG between 2 and 4 months after injection.


The average number of microaneurysms was 42.58±33.93 and significantly decreased to 28.74±28.06 after intravitreal injection of bevacizumab(p<0.05). The decrease of 35.70±24.79% in the treatment group was statistically higher than 13.95±38.21% in the control group of the fellow eye(p<0.05).


We observed that intravitreal bevacizumab injection reduces NV, CME and microaneurysm. So we can use this data to research microvacular changes in the retina.