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Oculocutaneous Albinism. A Case Report

SCIENTIFIC POSTER_Silvia Monteiro_1 Introduction: Oculocutaneous albinism (OCA) is a group of inherited disorders of melanin biosynthesis characterized by a generalized reduction in pigmentation of hair, skin and eyes. The prevalence of all forms of albinism varies considerably worldwide and has been estimated at approximately 1/17,000, suggesting that about 1 in 70 people carry a gene for OCA. The clinical spectrum of OCA ranges, with...

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Surgical Treatment of the Macular Pathologies in Patients with Pigmentary Retinal Abiotrophy

SCIENTIFIC POSTER_Tatyana Kurskaya General considerations: At the moment there is no effective treatment for pigmentary retinal atrophy. The existing treatment methods of this genetic disease are aimed at maintaining of the declining eye visual functions and slowing down the optic nerve atrophy development. According to some authors (Shamshinova A.M., 2001; Fishman G., 1977) the macular changes in pigmented retinitis are observed in 63-74%...

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Congress – The challenge of retinal transplantation.

on SYMPOSIUM: ARMD SURGICAL APPROACH Monday, June 20, 2005 ; 8:30 – 1:15 The Challenge of Retinal Transplantation Author: Peep V. Algvere, M.D., Ph.D., Relya Zivojnovic Award Abstract : Since several retinal diseases and dystrophies exhibit apoptotic cell death of photoreceptors and/or RPE cells, transplantation of young and healthy cells has been most desirable to replace the diseased tissue. A remarkable achievement was the...

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Serum and Proinflammatory Cytokines Affect the RPE in a Culture Model of Macular Degeneration

Ron A. Adelman (New Haven, CT, USA) Advantages: To develop a culture model of human fetal retinal pigment epithelium (hfRPE) to examine the effects of serum and proinflammatory cytokines on the tight junctions of the outer blood retinal barrier.  In the wet form of age-related macular degeneration (AMD), leaky capillaries grow in the subretinal space, exposing the apical side of the RPE to serum. Further, proinflammatory cytokines are...

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The Effect of Blue Light on Vascular Endothelial Growth Factor

Kourous A. Rezai, MD (Harvey, IL), Kasra Attaran Rezaei, MD (Chicago, IL), Elzbietta Gasyna, MS (Chicago, IL), Lili Farrokh-Siar, MD (Chicago, IL) PURPOSE: Vascular endothelial growth factor (VEGF) plays an important role in AMD. Further it has been suggested that exposure to blue light may also affect the progression of AMD. In this study we analyzed the effect of blue light on the production of VEGF in human retinal pigment epithelial...

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The RPE in Health and Disease: a Role for Lipofuscin and Melanin in ARMD

http://www.evrs.eu/medias/2005/congress/The-RPE-in-health-and-disease:-a-role-for-lipofuscin-and-melanin-in-ARMD.swf Mike Boulton – School of Optometry and Vision Sciences, Cardiff University, Cardiff CF10 3NB, UK The retinal pigment epithelium (RPE) is a single layer of post-mitotic cells, which functions both as a selective barrier to and a vegetative regulator of the overlying photoreceptor layer, thereby playing a key role in its...

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