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Super-selective Intraophthlamic Artery Melfalan for Management of Advanced Intraocular Retinoblastoma: Two-year Results

Purpose: To evaluate the role of superselective ophthalmic artery melfalan (SSOAM) for management of advanced retinoblastoma whether as a primary or secondary treatment modality. Methods: Ten cases of advanced stage D disease were managed by SSOAM. Seven cases presented after failure of other therapeutic modalities to control the tumor and 3 cases presented with advanced uniocular disease. SSOAM was given as initial therapy for 1-3...

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Retinoblastoma Tumor Vascular Heterogeneity: A Model for Angiogenic Vacular Maturation and Implications for Vascular Targeting Therapy

Timothy G. Murray, MD (Miami, FL),* Maria Elena Jockovich, PhD (Miami, FL), Yoland Pina, PhD (Miami, FL), Fernando Suarez, (Miami, FL), Sander Dubovy, MD (Miami, FL), Amy Schefler, MD (Miami, FL) PURPOSE: The purpose of this study is to evaluate blood vessel maturation in the murine transgenic model of retinoblastoma and to correlate with pediatric enucleated retinoblastoma tumors specimens to determine if vessel heterogeneity can be...

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