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Age Influence on the Results of Photodynamic Therapy of Subfoveal or Juxtafoveal Choroidal Neovascularisation in Pathologic Myopia

Leila El Matri, MD (Tunis, Tunisia), Fatma Mghaieth, MD (Tunis, Tunisia), Rym Bouraoui, MD (Tunis, Tunisia), Rim Limaiem, MD (Tunis, Tunisia), Sihem Meddeb, MD (Tunis, Tunisia) PURPOSE: To evaluate results and prognosis of photodynamic therapy in choroidal neovascularisation secondary to pathologic myopia and to identify potential relation between the visual outcome and the age at presentation. METHODS: Retospective study from February...

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Comparison of Photodynamic Therapy Combined with Immediate Versus Delayed Intravitreal Triamcinolone Acetonide for Choroidal Neovascularization

Ajay Dudani, MD (Mumbai, India), Alay S Banker, MD (Ahmedabad, Gujarat, India), J. Fernando Arevalo, MD, FACS (Caracas, Venezuela) PURPOSE: To examine the 12-month results of a group of patients treated with combined photodynamic therapy (PDT) with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization (CNV). METHODS: Retrospective analysis of noncomparative case series of 54 eyes with CNV which were treated...

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Macrophages Inhibit Neovascularization in a Murine Model of Agerelated Macular Degeneration (AMD)

Rajendra S. Apte, MD, PhD (St. Louis, MO), Thomas A. Ferguson, PhD (St. Louis, MO), Jennifer Richter, BS (St. Louis, MO), John Herndon, BS (St. Louis, MO) PURPOSE: CNV is the process by which abnormal blood vessels develop underneath the retina and lead to blindness in over 90% of patients with AMD. Although the precise etiology of CNV in AMD remains unknown, the macrophage component of the inflammatory response has been thought to be...

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Potential Future Advances in Ophthalmology from Research in Tumor Angiogenesis

http://www.evrs.eu/medias/2006/congress/Potential-Future-Advances-in-Ophthalmology-from-Research-in-Tumor-Angiogenesis.swf Judah Folkman, MD (Boston, MA) PURPOSE: Neovascular diseases of the eye comprise the most common cause of blindness. Pathological microvessels in the eye can grow rapidly or can remain stable for long periods of time. These vessels can invade normal tissues in the eye. Their hyperpermeability can lead to local edema,...

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Intravitreal Bevacizumab (Avastin) as Salvage Treatment of Refractory Choroidal Neovascularization and Macular Edema from Retinal Vascular Disease

Michael M. Lai, MD, PhD (Royal Oak, MI), Tamer F. Eliwa, MD (Royal Oak, MI), Antonio Capone, MD (Royal Oak, MI), Tarek S. Hassan, MD (Royal Oak, MI), Kimberly A. Drenser, MD (Royal Oak, MI) PURPOSE: To evaluate the anatomic and visual outcomes of intravitreal bevacizumab in patients with neovascular age-related macular degeneration (AMD), diabetic macular edema, and macular edema secondary to retinal vein occlusion unresponsive to...

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The Effect of HIF-1a Expression on Hypoxemic Bovine Retinal Endothelial Cells and Intervention

Aijun Deng, MD (Weifang, China), Deyong Jiang, MD (Changsha, China), Fengying Kang, MD (Weifang, China) PURPOSE: We investigated the sequential changes of HIF-1a in hypoxic bovine retinal microvessels endothelial cells exposed to cobaltous chloride (COCl2), and its effects on VEGF expression and proliferation of BREC. We also studyed the effects of HIF-1a ASODN on hypoxemic bovine retinal endothelial cells, in order to find the better...

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