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Bevacizumab for Subfoveal Choroidal Neovascularization in a Child

Poster Gavin Tan Introduction: Choroidal neovascularization (CNV) is rare but important cause of visual impairment in children. It is often idiopathic or secondary to inflammation, optic nerve head abnormalities or retinal dystrophies. There is a lack of clinical trials assessing the treatment of CNV in children. Methods: A 11-year-old boy with no past medical or ocular history presented with 3 months duration of reduced vision in his...

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Intravitreal Injection of Bevacizumab for the Treatment of Inflammatory Choroidal Neovascularization

Salim Ben Yahia, Bechir Jelliti, Rim Kahloun, Rim Ghrissi, Salah Jenzeri, Moncef Khairallah (Monastir, Tunisia) Advantages: To manage inflammatory choroidal neovascularization (CNV) with intravitreal injection of bevacizumab, since conventional therapeutic options, including laser photocoagulation, surgery, corticosteroids, and verteporfin therapy, have potential limitations and are associated with a high rate of recurrences. Methods:...

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Treatment of Non-AMD (Myopic, Inflammatory, Angioid Streak…) Subfoveal Choroidal New Vessels with Intravitreal Anti-VEGF Instead of Photodynamic Therapy

http://www.evrs.eu/medias/2008/congress/Treatment-of-Non-AMD-(Myopic,-Inflammatory,-Angioid-Streak…)-Subfoveal-Choroidal-New-Vessels-with-Intravitreal-Anti-VEGF-Instead-of-Photodynamic-Therapy.flv Catherine Favard, Martine Mauget-Faysse Advantages: Intravitreal anti-VEGF therapy appears very effective to treat AMD choroidal new vessels and shows no choroidal ischemia and does not induce VEGF upregulation when compared to photodynamic...

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Safety and Efficacy of Intravitreal Bevacizumab for Subfoveal Choroidal Neovascularization in Pathologic Myopia

Myriam Lucia Hernandez-Rojas, MD (Mexico City, Jose Dalma- Weiszhausz, MD (MexicoCity, Mexico), Hugo Quiroz- Mercado, MD (Mexico City, Mexico), Jans Fromow-Guerra, MD, PhD (Mexico City, Mexico), Griselda Alvarez-Rivera, MD (Mexico City, Mexico), Maura Abraham-Marin, MD (Mexico City, Mexico), Adriana Solis-Vivanco, MD (Mexico City, Mexico), Elizabeth Reyna-Castelan, MD (Mexico City, Mexico), Jose Luis Guerrero-Naranjo,MD (Mexico City,...

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The Effects of Combined Inhibition of Platelet-derived Growth Factor (PDGF-B) and VEGF-A Signaling in Murine Models of Ocular Neovascularization

http://www.evrs.eu/medias/2006/congress/The-Effects-of-Combined-Inhibition-of-Platelet-derived-Growth- Factor-(PDGF-B)-and-VEGF-A-Signaling-in-Murine-Models-of-Ocular-Neovascularization.swf Anthony P. Adamis, MD (New York, NY),* David R. Guyer, MD (New York, NY)* PURPOSE: While the inhibition of VEGF-A signaling can prevent new blood vessel growth in cancer and ocular pathologies, more mature vessels appear to be less susceptible. Since...

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Intravitreal Bevacizumab as Isolated First Line Therapy in Patients with New Untreated Choroidal Neovascular Membranes

http://www.evrs.eu/medias/2006/congress/Intravitreal-Bevacizumab-as-Isolated-First-Line-Therapy-in-Patients-with-New-Untreated-Choroidal-Neovascular-Membranes.swf Alay S Banker, MD (Ahmedabad, India), Marisa Flores-Aguilar, MD (Tijuana, Mexico), J. Fernando Arevalo, MD, FACS (Caracas, Venezuela) PURPOSE: To determine results of intravitreal bevacizumab in patients with choroidal neovascular membranes (CNVMs) of different types and...

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Age Influence on the Results of Photodynamic Therapy of Subfoveal or Juxtafoveal Choroidal Neovascularisation in Pathologic Myopia

Leila El Matri, MD (Tunis, Tunisia), Fatma Mghaieth, MD (Tunis, Tunisia), Rym Bouraoui, MD (Tunis, Tunisia), Rim Limaiem, MD (Tunis, Tunisia), Sihem Meddeb, MD (Tunis, Tunisia) PURPOSE: To evaluate results and prognosis of photodynamic therapy in choroidal neovascularisation secondary to pathologic myopia and to identify potential relation between the visual outcome and the age at presentation. METHODS: Retospective study from February...

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Comparison of Photodynamic Therapy Combined with Immediate Versus Delayed Intravitreal Triamcinolone Acetonide for Choroidal Neovascularization

Ajay Dudani, MD (Mumbai, India), Alay S Banker, MD (Ahmedabad, Gujarat, India), J. Fernando Arevalo, MD, FACS (Caracas, Venezuela) PURPOSE: To examine the 12-month results of a group of patients treated with combined photodynamic therapy (PDT) with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization (CNV). METHODS: Retrospective analysis of noncomparative case series of 54 eyes with CNV which were treated...

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Macrophages Inhibit Neovascularization in a Murine Model of Agerelated Macular Degeneration (AMD)

Rajendra S. Apte, MD, PhD (St. Louis, MO), Thomas A. Ferguson, PhD (St. Louis, MO), Jennifer Richter, BS (St. Louis, MO), John Herndon, BS (St. Louis, MO) PURPOSE: CNV is the process by which abnormal blood vessels develop underneath the retina and lead to blindness in over 90% of patients with AMD. Although the precise etiology of CNV in AMD remains unknown, the macrophage component of the inflammatory response has been thought to be...

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Potential Future Advances in Ophthalmology from Research in Tumor Angiogenesis

http://www.evrs.eu/medias/2006/congress/Potential-Future-Advances-in-Ophthalmology-from-Research-in-Tumor-Angiogenesis.swf Judah Folkman, MD (Boston, MA) PURPOSE: Neovascular diseases of the eye comprise the most common cause of blindness. Pathological microvessels in the eye can grow rapidly or can remain stable for long periods of time. These vessels can invade normal tissues in the eye. Their hyperpermeability can lead to local edema,...

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Intravitreal Bevacizumab (Avastin) as Salvage Treatment of Refractory Choroidal Neovascularization and Macular Edema from Retinal Vascular Disease

Michael M. Lai, MD, PhD (Royal Oak, MI), Tamer F. Eliwa, MD (Royal Oak, MI), Antonio Capone, MD (Royal Oak, MI), Tarek S. Hassan, MD (Royal Oak, MI), Kimberly A. Drenser, MD (Royal Oak, MI) PURPOSE: To evaluate the anatomic and visual outcomes of intravitreal bevacizumab in patients with neovascular age-related macular degeneration (AMD), diabetic macular edema, and macular edema secondary to retinal vein occlusion unresponsive to...

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The Effect of HIF-1a Expression on Hypoxemic Bovine Retinal Endothelial Cells and Intervention

Aijun Deng, MD (Weifang, China), Deyong Jiang, MD (Changsha, China), Fengying Kang, MD (Weifang, China) PURPOSE: We investigated the sequential changes of HIF-1a in hypoxic bovine retinal microvessels endothelial cells exposed to cobaltous chloride (COCl2), and its effects on VEGF expression and proliferation of BREC. We also studyed the effects of HIF-1a ASODN on hypoxemic bovine retinal endothelial cells, in order to find the better...

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VEGF Inhibition Study in Ocular Neovascularization (Vision): Outcomes from the Phase II/III Macugen Pivitol Trials

http://www.evrs.eu/medias/2005/congress/VEGF-Inhibition-Study-in-Ocular-Neovascularization-(Vision):-Outcomes-from-the-Phase-II-III-Macugen-Pivitol-Trials.swf Thomas R. Friberg and the Macugen Study Group Purpose: To evaluate the safety and effectiveness of Macugen in the treatment of exudative AMD. Methods: Two phase II/III randomized, double masked, multicentered trials were conducted to study the effect of pegatanib sodium (Macugen)...

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Photodynamic Therapy with Visudyne: Complications

Guy L’Helgoual’ch Purpose: To analyse the photodynamic therapy’s complications and try to understand parts of the mecanisms. Methods: Fluorescein and ICG angiograph are done using a Topcon Imagenet system Adobe Photoshop software to analyse the pictures and create traces from the lesion and laser’s spot area Morphing software to compare the angiographs. Results: Using Adobe photoshop software, it is possible to show the...

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Preferential Hyper Acuity Perimeter: Clinical and Angiographic Correlations

http://www.evrs.eu/medias/2005/congress/Preferential-hyper-acuity-perimeter:-clinical-and-angiographic-correlations.swf Guy L’Helgoual’ch Purpose: To appreciate the correspondence of P.H.P.’s results with angiograph’s pictures for patients cured for age related macular degeneration, treated or not. Methods: 9 months using P.H.P. during the follow-up of patients for age related macular Degeneration. Some of the patients have got a...

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Choroidal Neovascularization – from Mice to Man

Lennart Berglin, MD, PhD – St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden Many signs indicate an inflammatory reaction and a molecular breakdown of the bloodretina barrier in Bruchs membrane with age in choroidal neovascularization (CNV). The vascular response has many similarities with an unspecific wound healing process elsewhere in the body. New vessel growth (angiogenesis) can be triggered by a switch in a normally...

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OCT in Active Choroidal Neovascularization Secondary to Pathologic Myopia

http://www.evrs.eu/medias/2005/congress/OCT-in-active-choroidal-neovascularization-secondary-to-pathologic-myopia.swf Murat Karacorlu, MD, Serra Arf Karacorlu, MD, Hakan Ozdemir, MD – Istanbul Retina Institute, Inc. Istanbul, Turkey Purpose: To evaluate the early optical coherence tomography (OCT) changes after photodynamic therapy (PDT) in patients with subfoveal choroidal neovascularization (CNV) secondary to pathologic...

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Circular Macular Translocation in Selected Cases of CNV and Heavy Silicone Tamponade

Cesare Forlini, MD, Paolo Rossini, MD, Giuseppe Giunchiglia, MD, Roberto Lodi, MD – Department of Ophthalmology, S. Maria delle Croci Hospital, Ravenna, Italy Purpose: To evaluate the role of heavy tamponade in circular macular translocation. Methods: After PPVV we performed circular macular translocation and heavy silicone oil tamponade. 1 patient had age related macular degeneration with CNV and 1 atrophic age related macular...

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