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Detection of choroidal neovascularization using Optical Coherence Tomography Angiography compared to Traditional Angiography in Exudative Age-Related Macular Degeneration

SCIENTIFIC POSTER 2016_Detection of choroidal neovascularization using Optical Coherence Tomography Angiography compared to Traditional Angiography in Exudative Age-Related Macular Degeneration Purpose: To determine the sensitivity and specificity of optical coherence tomography angiography (OCTA) in detecting choroidal neovasculararization (CNV) compared to fluorescein angiography (FA) considered as the first choice technique. Methods: A...

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EVRS Floaters Study – The EVRS Floaters Study Results

Contact Details: Email: parolinibarbara@gmail.com  

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EVRS Floaters Study – Review of Literature

Contact Details: Email: ron.adelman@yale.edu  

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Comparison of the Effect of Ranibizumab and Aflibercept for Choroidal Thickness Changes in Wet AMD

SCIENTIFIC POSTER 2016_Comparison of the Effect of Ranibizumab and Aflibercept for Choroidal Thickness Changes in Wet AMD Hee Seong Yoon Purpose: To compare the changes in subfoveal choroidal thickness (SFCT) after intravitreal ranibizumab or aflibercept injections for neovascular age-related macular degeneration (nAMD). Methods: Medical records of 67 treatment-naive patients (69 eyes) who were diagnosed with neovascular AMD (nAMD) and...

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Clinical Outcomes and Safety of Nd-YAG Laser Vitreolysis for Symptomatic Vitreous Floaters

SCIENTIFIC POSTER 2016_Clinical Outcomes and Safety of Nd-YAG Laser Vitreolysis for Symptomatic Vitreous Floaters Seong Joo Shin Purpose: To evaluate the clinical outcomes and safety of Nd:YAG laser vitreolysis for symptomatic vitreous floaters. Methods: This was prospective interventional study of 42 eyes of 42 patients with symptomatic floaters lasting more than 6 months. The vitreous floaters were photodisrupted with Ultra Q Reflex...

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Choroidal Neovascular Membrane in Children

SCIENTIFIC POSTER 2016_Choroidal Neovascular Membrane in Children Maha M. Elshafei Case 1: A case of seven-year-old girl who presented to the eye clinic complaining of decreased vision in both eyes. Examination showed bilateral active choroidal neovascular membrane in the macular area, which was, treated with multiple intravitreal injections of Ranibizumab. Screening of the family showed bilateral Vitilliform maculopathy in the younger...

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Response of Pigment Epithelial Detachment to Anti-VEGF Treatment in AMD

SCIENTIFIC POSTER 2016_Response of Pigment Epithelial Detachment to Anti-VEGF Treatment in AMD Han Joo Cho Objective: To evaluate the therapeutic response of pigment epithelial detachment (PED) to anti-vascular endothelial growth factor (VEGF) treatment in neovascular age-related macular degeneration (nAMD), and identify predictive factors for PED resolution after treatment. Methods: A total of 202 treatment-naive nAMD eyes presenting PED...

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Results of Intravitreal Aflibercept in Insufficient Responders to Prior Anti-VEGF Therapy in Neovascular AMD

SCIENTIFIC POSTER 2016_Results of Intravitreal Aflibercept in Insufficient Responders to Prior Anti-VEGF Therapy in Neovascular AMD Zeynep Alkin Purpose: To report the outcomes of intravitreal aflibercept therapy in eyes with refractory neovascular age-related macular degeneration (AMD) switched from intravitreal bevacizumab or ranibizumab. Methods: This is a retrospective review of eyes with neovascular AMD switched to intravitreal...

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My Strategy for Floaters

People know that. I’m the first to fight against vitrectomy in a detachment without PVD, to fight against combined surgery when we can avoid it, or to call for a minimal vitrectomy in macular surgery as my concern is always to provoke the minimum trauma; but I am performing 10 to 15 vitrectomies per year for floaters and this can appear paradoxical. I have 2 indications Professional indications: a commercial traveler who cannot drive his...

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Our Experience in Treating Floaters

Treatment for symptomatic floaters range from floater reduction using laser strategies to full vitrectomy necessitating a surgical PVD. Furthermore, patient’s individual perceptions of vitreous opacities differ significantly, and therefore treatment strategies must respect their expectations. A subgroup of patients suffers heavily and is almost not able to continue normal daily life or work, although floaters are hardly detectable by...

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Vitrectomy for Floaters – Risks versus Benefits

Purpose: To review the outcome of small gauge vitrectomy for symptomatic floaters and compare risks versus benefits. Background: Floaters can be a symptomatic condition due to partial liquefaction of vitreous gel or accumulation of opacities in vitreous. Patients may complain of a variety of visual symptoms, which can be potentially disabling. This phenomenon may or may not be associated with posterior vitreous detachment (PVD) which is...

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My Strategy for Floaters

Pars plana vitrectomy (PPV) provides the most effective treatment for floaters as it offers a definitive cure with complete resolution of symptoms. However, this procedure is invasive with the possibility of complications such as endophthalmitis, retinal tears and detachments, cataract formation, glaucoma, vitreoretinal hemorrhage, and macular edema . Therefore, it is important to only advocate vitrectomy to cure floaters for patients who...

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Vitreous Floaters Not Only in Young Anxious Engineers

Advantages: 1. Vitrectomy helps in all kinds of vitreous opacities. 2. We broke the concept that the typical patient with vitreous floaters is a young anxious engineer. Methods: We analyzed 83 eyes of 63 patients who underwent vitrectomy for vitreous floaters (asteroid hyalosis, PVD, and floaters only) between 2010 and 2015. 47 were male, 36 female eyes. Their mean age was 60 years, ranging from 22 to 82; the median was 61. The mean...

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Floaters Surgery

Vitreous floaters could result from vitreous seneresis or as result of vitreoretinal diseases such as intraocular inflammation or vitreous haemorrhage. In the absence of associated vitreoretinal disease, most patients with vitreous seneresis- related floaters learn to live with their symptoms. However, surgery is justifiable in some patients whose quality of vision is compromised because of significant floaters. It is important to carefully...

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Photoreceptors Exhibit Optical Fiber Property Due to Physical Properties, Including Their Shapes, Diameters and Indices of Refraction

Photoreceptors exhibit optical fiber property due to physical properties, including their shapes, diameters and indices of refraction. Because of their wave-guiding properties, visual perception of light is weakened by the obliquity of the incident rays. Light rays passing through the centre of the pupil appear brighter than peripheral rays. This phenomenon is called the Stiles-Crawford effect. In an emmetropic eye, every wave front related...

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Short-term Safety Profile of Intravitreal Ziv-aflibercept

Aim: To evaluate the safety of intravitreal ziv-aflibercept (Zaltrap®) in the treatment choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Methods: Eligible eyes with CNV secondary to AMD each received a single intravitreal injection of ziv-aflibercept. Comprehensive ophthalmic examinations and detailed systemic evaluations were performed at baseline, and days 1, 7, and 30 after injection, and...

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Effectiveness of Low-energy Light Irradiation for Exudative AMD After Anti-VEGF Therapy

Studied the effectiveness of low-energy light irradiation in patients with exudative form of age-related macular degeneration after anti-VEGF therapy. The main group included 62 patients (the 69 eyes), who received two courses of low-energy light radiation within 6 months after the anti-VEGF therapy. A control group of 41 patients (44 eyes) to the monitoring took place only anti-VEGF therapy. The total period of observation was 1 year....

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Eylea in the Treatment of Wet AMD : Comparison of Different Treating Regimens

Advantages: We compared different regimens of aflibercept (EYLEA) injections in patients with wet AMD. Methods: We analyzed 195 eyes of 186 patients with wet AMD, treated between 2013 and 2015 with aflibercept. We assessed BCVA and central retinal thickness and compared these parameters in four subgroups of patients treated using four different regimens: Only three monthly loading doses. Three loading doses followed with individual...

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Individualized Anti-VEGF Treatment Approach for Neovascular AMD

Aim: To describe the individualized treatment schedule for each neovascular ARMD patient combining PRN and proactive treatment approach. Methods: There are different treatment approaches considering the anti-VEGF treatment for neovascular ARMD. These are monthly treatment, fixed dose with more than monthly intervals or individualized treatments which can be either PRN or treat & extend or wait & extend or observe & plan...

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Stargardt Color and Autofluorescence

              The image is a collage of the bilateral color and autofluorescence capture of a young boy with Stargardt disease stage 3a. Contact Details: Email: parolinibarbara@gmail.com Cell Phone:...

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Pattern Choroidal Dystrophy

              Contact Details: Email: ihabsaad@hotmail.com Cell Phone:...

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An Atypical Case of Persistant Subretinal Fluid, Mimicking a Unilateral Acute Exudative Polymorphous Vitelliform Maculopathy or a CSC

                  Introduction: To describe the case of an atypical Persistent Subretinal Fluid presentation following a macula ON R.D. Results: A 64 y.o woman developed a Macula ON retinal detachment extending from 5 to 11 o’clock, with a unique retinal break at 10 o’clock but threatening the Macular area. For such reason, a vitrectomy was realised to drain the subretinal fluid...

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Wet AMD After Vitrectomy for RD

Presentation shows two cases of choroidal neovascularisation after vitrectomy. Both cases undergo two surgical procedures. In first case the second procedure was performed to remove epiretinal membrane which causes macular edema. Second case was PVR detachment surgery treated in two operations. In first procedure we attached retina with silicone oil tamponade and 180 degrees retinectomy, and in second one we peel membranes and remove...

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Comparison of Clinical Characteristics in Myopic Traction Maculopathy with and Without MH

So Hyun Bae_SCIENTIFIC POSTER 2015 Purpose: To compare the clinical characteristics of myopic traction maculopathy (MTM) with and without macular hole (MH). Methods: This retrospective study included the patients with MTM who underwent vitrectomy. The eyes were subdivided into 2 groups based on the presence of MH. Clinical features were assessed including age, sex, axial length, visual acuity, posterior staphyloma, chorioretinal atrophy and...

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Secondary Angle Closure Glaucoma – An Unusual Complication of Polypoidal Choroidal Vasculopathy

Prabu Baskaran_SCIENTIFIC POSTER 2015 We report an unusual catastrophic complication of Polypoidal Choroidal Vasculopathy (PCV) despite an initial satisfactory response to treatment. A 67 year-old female presented to us in July 2012 with defective vision in RE since six months. She was a known hypertensive and diabetic on treatment since 15 years. There was no history of trauma, blood dyscrasias or use of any anticoagulants. On examination,...

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Effects of Intravitreal Aflibercept on Patients with Polypoidal Choroidal Vasculopathy: Results of VAULT Study

Woohyok Chang_SCIENTIFIC POSTER 2015_2 Purpose: To investigate efficacy of intravitreal aflibercept injection in patients with treatment-naive polypoidal choroidal vasculopathy (PCV). Methods: A prospective, multi-center, single-arm, interventional case series conducted in South Korea. Forty seven patients with polypoidal choroidal vasculopathy (PCV) confirmed using indocyanine green (ICG) angiography were enrolled. Aflibercept (2.0 mg) was...

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Monthly Alternating Injections of Aflibercept and Bevacizumab for Wet AMD

June Gone Kim_SCIENTIFIC POSTER 2015 Purpose: Every 2-months after 3 initial monthly doses had been used as a standard regimen of intravitreal aflibercept for the treatment of wet AMD. In clinical practice, however, bimonthly aflibercept is insufficient for the maintenance in some cases. This study was designed to investigate the efficacy of monthly alternating injections of aflibercept and bevacizumab for maintenance treatment of wet...

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Refractory Subfoveal Subretinal Fluid in Neovascular ARMD: Is There a Protective Effect on Good Visual Acuity?

Purpose: To investigate the functional outcome of eyes with neovascular age-related macular degeneration (nAMD) treated with ranibizumab which retain good visual acuity despite chronic, persistent subretinal fluid (SRF). Methods: This retrospective, interventional case series included 12 eyes of 11 patients with nAMD which have (mean age, 70.2 years; range, 58 to 78 years) persistent SRF despite anti-VEGF therapy, and good long-term visual...

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Problems of Anti-VEGF Therapy in Massive Subretinal Hemorrhage in Wet AMD

Actuality: In most cases, the period and the gradual reduction of visual acuity in AMD allows patients to adapt to low vision without a sudden loss of central vision and independence. In case of a massive subretinal hemorrhage on the basis of AMD, patients experience sudden loss of central vision and the associated debasement in the quality of life. A-VEGF therapy in the treatment of subretinal hemorrhage, appears ambiguous. Changes in...

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Six Months Results of Aflibercept versus Ranibizumab for Treatment of Wet-AMD

Oh Jae Kim_SCIENTIFIC POSTER 2015 Purpose: To compare the six-month clinical results of ranibizumab with aflibercept for the treatment of wet age-related macular degeneration (wet-AMD). Methods: Medical records of 44 eyes of 44 patients who underwent intravitreal ranibizumab (0.5mg / 0.05ml) or aflibercept (2.0mg / 0.05ml) injection for wet-AMD with more than 6 months of follow-up were reviewed retrospectively. All patients were treated...

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Idiopathic Choroidal Neovascular Membrane in a 9 Years Old Child

Veronica Ramos Camara_SCIENTIFIC POSTER 2015 An 8-years-old boy was referred to our service for evaluation of decreasing vision in his right eye. Personal Background: Patent ductus arteriosus surgery. His family denied history of trauma or inflammation. His best corrected visual acuity in his right eye was light perception and 20/20 in his left eye. Retinography showed subfoveal choroidal neovascular membrane (CNVM) with subretinal...

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An Unusual Case of CNVM with Subretinal Pigment Epithelial Hemorrhage in a Proved Case of Light Chain Disease with Kidney Failure

Sufiyan Shaikh_SCIENTIFIC POSTER 2015 We report a case of CNVM with RPE degenerative changes with sub RPE detachments in biopsy proven light chain nephropathy in a 33 year old female. A fundus change over a period of 3 years was monitored from the initial vis it. The patient underwent best corrected visual acuity (BCVA), fundus photography and ultrasound in the right eye during the initial visit of presentation. In the follow up visit after...

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Angiographic Features in Drug-induced Bilateral Angle Closure and Transient Myopia with Ciliochoroidal Effusion

Jae Pil Shin_SCIENTIFIC POSTER 2015_1 Purpose: To report angiographic findings of acute drug-induced angle closure and transient myopia with ciliochoroidal effusion. Methods: Slit lamp examination, intraocular pressure (IOP) measurement, ultrasound biomicroscopy (UBM), fluorescein angiography (FAG) and Indocyanine green angiography (ICGA) were performed in 4 patients who had acute drug-induced angle closure with ciliochoroidal...

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Association of Complement Factor H Y402H Gene Polymorphism and Serum CFH with Risk of AMD in Egyptian Patients

Background: Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in the elderly population worldwide. Numerous genetic studies have suggested that Complement Factor H (CFH) Y402H polymorphism might be associated with AMD, in different populations with contradictory findings; however, the Egyptian population was understudied. The aim of this study is to examine whether there is an association between...

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TTT-like Laser Coagulation of Peripapillary Neovascular Membranes

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   In eyes with AMD or other choroidal pathologies prone to develop subretinal neovascular membranes we occasionally encounter cases where the CNV is localized around the optic disc, giving rise to an exudative retinal detachment frequently involving the macula and reducing visual function. When the CNV does not involve the foveal zone...

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Gloucestershire Model for Treating Neovascular ARMD – An Industrial Production Line!

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   The management of patients with neovascular age related macular degeneration (nAMD) forms a large and increasing proportion of hospital eye service activity worldwide, particularly since the introduction of intravitreal anti-VEGF therapy. The delivery of anti-VEGF therapy has created substantial service pressures on ophthalmology...

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Personalized Medicine Applied to AMD

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   Introduction: AMD is a multi factorial disease triggered by aging (parainflammation), and genetic, cardio-vascular, inflammatory and environmental factors. The natural history of the disease shows that 80% of neovascular membranes are occult and that their natural course is a succession of relapse and remission phases. Patients and...

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Reasons for Aflibercept Prescription in Wet AMD in Real Life

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   Purpose: To describe the main reason for aflibercept prescription in the treatment of exudative age-related macular degeneration (AMD) during the initial weeks of availability of this drug in a clinical setting. Patients and methods: During the first 16 weeks of availability in France, four experienced practitioners in retinal disease...

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Epiretinal Membranes in Neovascular Age-related Macular Degeneration: Effect on Outcomes of Anti-VEGF Therapy

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   Introduction: Vitreomacular interface changes of AMD patients such as posterior vitreous detachment (PVD), vitreomacular adhesion (VMA) and vitreomacular traction (VMT) have been addressed in several clinical studies using optic coherence tomography (OCT).However role of epiretinal membrane (ERM) has not been investigated in the concept...

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Primary Combination Therapy for Exudative ARMD

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   Objective: Efficacy of Primary ICG-directed PDT Triple Therapy with verteporfin (Visudyne), ranibizumab (Lucentis), and triamcinolone acetonide (Triescence) versus €˜Standard of Care, i.e. anti-VEGF monotherapy, for the treatment of Exudative ARMD. Design: Retrospective, non-randomized, exploratory study. Methods: 2 year study of 115...

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Structural Changes of Choroidal Neovascularization in Indocyanine Green Angiography After Ranibizumab Injection

SCIENTIFIC POSTER_Il Han Yun Purpose: To investigate the mechanism of choroidal neovascularization (CNV) recurrence followed by intravitreal ranibizumab injections based on vascular structural changes of choroidal neovascularization (CNV) using indocyanine green angiography (ICGA) Methods: A total of 31 patients with exudative age-related macular degeneration and CNV whose structures were identifiable in ICGA. Patients with either...

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Peripapillary Intrachoroidal Cavitation in Myopic Patient

Myopic patients more than -6 diopters may suffer from this newly recognized pathology previously termed peripapillary detachment in pathologic myopia. It affects 5 % of highly myopic eyes. Usually a yellowish round lesion can be observed inferiorly to the optic nerve during fundus examination. We described that complex forces like posterior expansion force, vitreous traction force, and vitreous fluid dynamics determine the size and shape of...

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Choroidal Thickness in Highly Myopic Eyes

SCIENTIFIC POSTER_Mafalda Mota Purpose: Myopia (nearsightedness) is a prevalent disease. In the myopic eye the light rays focus anteriorly to the retina. High or pathologic myopia is defined as spherical equivalent refractive error greater than 6.00 diopters (D) or axial length greater than 26.5mm3. Patients with high myopia are at a greater risk of developing progressive retinal degeneration and other vision threatening pathology, such as...

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Morphology of PED as a Predicting Factor of Outcomes for Anti-VEGF Therapy of Wet AMD

SCIENTIFIC POSTER_Elena Kozina OCT-criteria for a potential risk of pigment epithelium (PE) tear development, PE reattaching and PED resistance at A-VEGF therapy of patients with wet AMD, accompanied by high PE detachment are determined retrosprctively for predicting the possible treatment outcome and determination of the optimal mode of A-VEGF injection. General Considerations: In clinical practice the different morphological forms of...

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Spontaneous Closure of a Myopic MH in a Vitrectomized Eye

We report on a 50 years-old female patient who underwent pars plana vitrectomy for a dropped nucleus and developed thereafter a myopic macular hole. The hole closed spontaneously during follow up. The patient had been referred to our clinic for a dropped nucleus on both eyes, and she underwent subsequent pars plana vitrectomy. We did not implant an intraocular lens because of the high myopic refraction. After surgery her visual acuity was...

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Refractive Errors in High Myopic Eyes After Phacovitrectomy

SCIENTIFIC POSTER_Ji Wook Yang Purpose: To examine the postoperative refractive error in highly myopic eyes after phacovitrectomy. Setting: University clinic, Suwon, Kyounggi-do, South Korea. Methods: This retrospective study includes 101 eyes (21 high myopic, 80 non-high myopic eyes) of 101 patients who underwent successful phacovitrectomy (phacoemulsification, intraocular lens implantation and pars plana vitrectomy). The highly myopic...

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Two Different Options in the Treatment of Premacular Hemorrhage Secondary to Macroaneurysm

  SCIENTIFIC POSTER_Ines Coutinho Purpose: Premacular hemorrhage is one major cause of sudden visual loss and occurs in a variety of disorders, among others in retinal arterial macroaneurysms (RAM). Possible therapeutic options include observation, vitrectomy, intravitreal rT-PA injection or laser posterior hyaloidotomy. However, the best treatment is still controversial. We report on 2 cases with premacular haemorrhage due to RAM. The...

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Surgical Tricks for Beginners in Small Gauge Vitrectomy in Pathologic Myopia

SCIENTIFIC POSTER_So Hyun Bae Introduction: Pathologic myopia is characterized by excessive axial elongation with progressive degeneration of the posterior pole. It is often associated with posterior staphyloma or patchy chorioretinal atrophy at the posterior pole. In addition, it may lead to various complications requiring surgical management including myopic traction maculopathy and macular hole with or without retinal detachment....

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Course 2014: Pathologic Myopia

Definition of pathologic myopia (syn. degenerative myopia) is not uniform. From the view­point of the clinician, axial myopia associated with structural changes of the posterior globe describes the condition most properly, as these alterations may threaten visual acuity. Refraction errors greater than 8 diopters are frequently associated with visual dysfunction. The prevalence of high myopia is apparently increasing, particularly in some...

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Progression of Myopic Maculopathy After Treatment of Myopic CNV

The progression of myopic maculopathy may affect the long-term VA outcome of myopic CNV treatment. We evaluated the long-term progression of myopic maculopathy and functional outcome after treatment of myopic choroidal neovascularization (CNV) with photodynamic therapy (PDT) and/or intravitrealranibizumab (IVR). This was a retrospective study with a cross-sectional evaluation, including fifty-four eyes with a mean follow-up of 80.6 ± 28.0...

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Myopic Choroidal Neovascularization

Pathological myopia is a common cause of visual impairment worldwide. Choroidal neovascularization (CNV) is its most threatening complication, often resulting in irreversible deterioration and loss of central vision. The precise pathogenesis of this disease remains unclear and several theories have been proposed. Improvements have been made in the diagnosis and characterization of myopic CNV over the years but there are no recognized...

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Myopic Maculopathy – A Review

Pathological myopia (PM) is a leading cause of legal blindness in many developed countries, particularly in young people. It is usually defined as an axial length ≥ 26,5 mm and/or a refractive error of at least -6,00 D and characteristic posterior pole abnormalities. The prevalence of the disease shows a wide variation among different ethnic groups, being higher in Asian populations and lower in African and Pacific Island groups. PM is a...

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Cine-angiography ICG Demonstrates Choroidal Re-perfusions After Vortex Vein Occlusions in AMD

Choroidal volume is reduced along aging. Choroidal perfusion is decreased by 37% in AMD (Grunwald JE1998) (1) Choroidal thickness is reduced by 50% (EDI-OCT study-Spaide RF 2009) (2) Vortex Veins Occlusion (VVO) might restaure choriocapillaris perfusion. (Hayreh SS 1982, experiments in the Rhesus monkey) (3) and (Bonnet M 1985, surgery in 17 human eyes with AMD) (4). The goal of the study was to evaluate the choroidal perfusion after...

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Suprachoroidal Macular Buckling for Myopic Traction Maculopathy

Advantages: Myopic traction maculopathy (MTM), also known as myopic foveoschisis, describes the schisis-like thickening in the outer layers of highly myopic eyes with posterior staphyloma. Other findings may also include inner retinal fluid, foveal detachment, and lamellar or full-thickness macular holes followed by progressive retinal detachment. Suprachoroidal buckling (SCB) procedure is a new approach for treating MTM by creating...

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Intravitreal Procrit in Eyes with Geographic Atrophy Secondary to ARMD

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   Purpose: To investigate the role of Procrit intravitreal injections in stabilizing vision and geographic atrophy (GA) in eyes with atrophic AMD and to characterize SD-OCT and central visual field acuity perimetry (Omnifield) findings associated with GA. Methods: A retrospective pilot study examined eyes treated off-label with Procrit...

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Cine-angiography ICG Demonstrates Choroidal Re-perfusions After Vortex Vein Occlusions in AMD

Media not available due to technical recording problems. EVRS is very sorry for the inconvenience.   Choroidal volume decreases with age. Choroidal perfusion is also decreased by 37% (Grunwald JE1998)- 50% (EDI-OCT study-Spaide RF 2009) in AMD. Vortex Veins Occlusion (VVO) might restore choriocapillaris perfusion. (Hayreh SS 1982, experiments in the Rhesus monkey, Bonnet M 1985, surgery in 17 human eyes with AMD). The goal of the study...

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The Arrest of Dry AMD Development by Means of LED-based Low-light Therapy. The Dynamic of Acuity and Macular Pigment Optical Density

Advantages: To arrest the dry AMD development the original low-light therapy during two sessions in the course of year was used. Methods: To apply the low-light therapy the Vision Aid Mark-III prototype was used to illuminate retina by three different wavelengths of light. To evaluate the optical density of the macular pigment, the MacuLux® Praxis (Ebiga VISION GmbH, Germany) was used. Effectiveness: The main group consist of 90...

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Expression Pattern of Extracellular Matrix Components After Ranibizumab for Neovascular ARMD

Poster Malgorzata Nita Purpose: The aim of the study was to evaluate the effect of loading doses of ranibizumab on gene expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in patients with CNV/AMD. Setting: Study was conducted by the Department of Ophthalmology, Medical University of Silesia, Independent Public Clinical Hospital, Katowice, Poland. Methods Inclusion criteria: patients ≥60...

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Ocular Adverse Events Related to Intravitreal Ranibizumab in Patients with Exudative ARMD

Purpose: Anti-VEGF injections have been standard treatment of exudative age-related macular degeneration (ARMD) in recent years. However multiple and recurrent injections needed to maintain the efficacy of the treatment may lead to adverse side effects related to this regimen. The aim of this study was to find out ocular adverse events associated with intravitreal injection of ranibizumab for the treatment of exudative ARMD performed in a...

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Retinal Nerve Fiber Layer Thickness Change in Wet AMD Treated with Ranibizumab

Poster Ozen Ayranci Osmanbasoglu Advantages: To assess the effect of intravitreal (IV) ranibizumab therapy on retinal nerve fiber layer (RNFL) thickness. Methods: Fourteen eyes of 11 treatment naive patients with neovascular age related macular degeneration treated with ranibizumab were included. Patients were followed up by monthly examinations and IV ranibizumab injections were done as on needed basis. RNFL thickness s was measured by...

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High Intensity Thermal Laser in Non-subfoveal Polypoidal Choroido Vasculopathy – An Effective Method

Advantages: In non-subfoveal idiopathic polypoidal choroido vasculopathy (IPCV) cases, the high to moderate intensity green laser along with or with out anti-vascular endothelial growth factor (anti-VEGF) injections may be tried with good success in cases refractory to photodynamic therapy (PDT). Methods: Five eyes of five patients were studied retrospectively. Two patients were male and three patients were female, the age group ranging...

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Morphological Changes in Spectral Domain Optical Coherence Tomography Guided Bevacizumab Injections in Wet AMD, 12-months Results

Advantage: This paper aims to describe retinal changes during Spectral Domain Optical Coherence Tomography (SD-OCT) guided Bevacizumab treatment for neovascular age- related macular degeneration (AMD). Material and Methods: 47 eyes of 45 patients with wet AMD treated on demand with Bevacizumab. We used 3-dimensional SD-OCT to measure photoreceptor defects and subretinal fibrosis. The main efficacy endpoints were the SD-OCT measurements...

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Early Onset Exudative AMD Detected with Monthly SD-OCT with Eye-tracking of the Fellow Eye in Patients Treated with Anti-VEGF

Advantage: To determine the frequency and characteristic features of new- onset neovascularization (CNV) in age related macular degeneration (AMD) with spectral domain optical coherence tomography (SD-OCT). Methods: Prospective, observational study of 68 patients with unilateral CNV treated with Bevacizumab. SD-OCT and visual acuity (logMAR) was measured at baseline and then monthly in both, the Bevacizumab treated eye and in the study...

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Ranibizumab vs Bevacizumab vs Combined Therapy PDT-Ranibizumab for the Treatment of Age-related Macular Degeneration: One-year Follow-up

Advantages: To compare the efficiency of three different treatments analyzing the changes in visual acuity (VA), number of used doses and costs. Methods: In a randomized prospective study we created three groups: Group-A, where we administered 0.5 mg (0.05ml) of intravitreal (IV) Ranibizumab, for three consecutive months; Group-B, where we combined the photodynamic therapy together with an IV injection of Ranibizumab; Group-C, where we...

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Choroidal Vasculopathy Polipoydal. PTD guided by ICG. Long-term Period Results

Advantages: To evaluate the long-term outcome of patients suffering from symptomatic polypoidal choroidal vasculopathy (CVP), treated with focal photodynamic therapy (PDT), guided by indocyanine green (ICG). Methods: A prospective study of 11 eyes of 10 patients. Initially treated with focal PDT-VI guided. In 11 eyes the minimum follow up was 12 months, 9 eyes of 24 months, 7 to 36 months, 4 of 48 months and 3 to 60 months. We evaluated...

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Combined Intravitreal Anti-VEGF & Subtenon Corticosteroids in AMD to Reduce ME Recurrence

Purpose:  To evaluate combined treatment of Anti-VEGF & subtenon corticosteroids for recurrent macular edema (ME) associated to choroidal neovascularization (CNV) due to age related macular degeneration (AMD). Material & Methods: Cases of CNV in AMD were included in this retrospective study. All types of CNV could be included (classic, minimally classic, occult, PEDs) Results: This combined therapy seemed to decrease ME...

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Pedunculated choroidal – RPE Patch Transplantation in Severe Neovascular Macular Degeneration

Advantages: To perform an autologous RPE graft in a case of fibrotic CNV leaving a link between the patch and the original site of it. Methods: Standard vitrectomy with induction of retinal detachment and retinectomy of the 180° temporal retina; removal of fibrotic subfoveal fibrotic membrane, preparation of a choroidal patch to move on the macular area leaving a part connected with the original site of choroid. Effectiveness / Safety:...

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Tachyphylaxis During Ranibizumab Treatment of Exudative Age-related Macular Degeneration

Purpose: To determine the rate of tachyphylaxis during Ranibizumab therapy for exudative age-related macular degeneration (AMD). Methods: The records of patients treated with Ranibizumab were retrospectively reviewed. Tachyphylaxis was defined as an initial good response to Ranibizumab followed by a decrease or absence of the response to Ranibizumab despite a minimum of two injections du ring follow-up in patients with exudative...

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Surgical Approach to Massive Subretinal Hemorrhages Secondary to Neovascular ARMD

Purpose: Different surgical management of massive subretinal hemorrhage secondary to ARMD will be defined. Methods: Pars plana vitrectomy (PPV) with 360 retinotomy and removal of subretinal hemorrhage and membrane +/- choroidal patch graft is performed to 3 cases of massive subretinal hemorrhage secondary to ARMD and the results and surgical videos will be presented. Take home message: Subretinal surgery is unavoidable in such cases to...

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Individualized Approach to Neovascular ARMD Treatment

Purpose: To define a new approach for treatment of neovascular ARMD cases with less frequent visits and injections. Methods: Neovascular ARMD cases that have been followed-up for 1-2 year period were analyzed retrospectively and those who had regular intervals of recurrence were identified. An individualized visit and injection period was defined for each of those patients separately. Effectiveness: Those cases that had regular...

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CNV in AMD

Autologous RPE and choroid transplantation for the treatment of CNV in AMD will be presented in details.

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PPV with Choroid-RPE Patch Graft for Massive Hemorrhage Due to Neovascular ARMD

This is a video of a patient with age related macular degeneration who had a macular scar in his right eye and a new subretinal massive hemorrhage causing hemorrhagic retinal detachment in his left eye which used to be his better eye. A cataract surgery combined with pars plana vitrectomy with 360 retinotomy, removal of subretinal hemorrhage, clots and choroidal neovascular membrane, and choroid-retina pigment epithelial patch graft was...

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Removing the Submacular Scar

Submacular scar in long standing age related macular degeneration cases severly compromise the vision and vis a vis the day to day activity of the person thus affected. Minimum improvements in the vision make these patients happier. It helps them with at least the benefit of improved field of vision. Here we describe surgery in a patient with long standing macular scar. Novel instrumentation technique was used to make a sub macular cannula....

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Autologous Transplantation of RPE & Choroid for Wet AMD: Functional Results and Prognostic Factors After a Long-term Follow-up

Advantages: Choroidal neovascularization in age related macular degeneration (AMD), non-responder to standard care, might be treated with autologous transplantation of retinal pigment epithelium and choroid (PATCH). The purpose was to define prognostic criteria for this surgery, to improve the result. Methods: Thirty eyes underwent PATCH surgery. Follow-up was 36 months. Patients received ETDRS, OCT scan and fluorescein and indocyanine...

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Do Neovascular AMD Lesions Associated with PED Behave Differently to Anti-VEGF Treatment?

Purpose: To document the prognosis of eyes with neovascular AMD associated with any pigment epithelial detachment (PED) during the course of anti VEGF treatment. Methods: The medical records of 331 eyes with neovascular AMD treated with intravitreal anti VEGFs were retrospectively errate for the presence of PED. The visual and anatomical (OCT) prognosis of the cases and complication rates after treatment were determined. Results: PED was...

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Intravitreal Ranibizumab for Best’s Vitelliform Macular Dystrophy in a 38 Year-old Asian Woman

Advantages: To describe the effect of intravitreal ranibizumab for the treatment of choroidal neovascularisation and macular edema secondary to Best’s vitelliform macular dystrophy. Methods: A 38-year-old Asian woman with confirmed Best’s disease presented with decreased visual acuity (VA) due to secondary choroidal neovascularisation and macular edema. She was treated with a single intravitreal injection of ranibizumab (Lucentis, 0.5...

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Proteomics in Exudative AMD

Purpose: To errate and compare vitreous samples of exudative AMD with these of floater patients with PROTEOMICS. Methods: Twenty-three vitreous samples (15 AMD and 8 controls) from patients undergoing 23 gauge single-site core vitrectomy for combined intravitreal treatment were errate with capillary electrophoresis coupled to mass spectrometry. Results: A total of 5949 polypeptides (PP) could be defined in all samples based on mass,...

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Combined Treatment with Sub-tenon Injection of Triamcinolone and Intravitreal Anti-VEGF Injection in Refractory Neovascular ARMD

Advantages: Combined treatment with sub-Tenon’s injection of triamcinolone and intravitreal anti-VEGF injection has beneficial effect in improving visual acuity and anatomic outcomes in refractory neovascular AMD patients. Methods: Seven eyes of 7 patients with refractory neovascular age-related macular degeneration (AMD) secondary to polypoidal choroidal vasculopathy (PCV) were enrolled. Refractory PCV was defined as no response of...

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Relationship of Elevated Osteoprotegerin with Exudative ARMD

Purpose: The aim of the present study was to elucidate if there is any relationship between osteoprotegerin (OPG) and exudative age-related macular degeneration (E-AMD), a disease with similar risk factors as coronary artery disease. Methods: In a cross-sectional study, we compared 45 E-AMD patients with 45 matched controls. Diagnosis was confirmed by fluorescein angiography. Serum samples were analyzed for OPG, RANK Ligand, low-density...

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The Effect of Anti-VEGF Treatment on Fundus Fluorescein Angiographic Findings in AMD Cases

Advantages: To analyse the effect of anti-VEGF treatment on arm to retinal circulation, capillary time, venous filling time, retinal artery and vein diameters measured by fluorescein angiography. Methods: Patients who had at least three anti-VEGF injections were included in the study. Patients were grouped (n: 72) regarding the intravitreal treatment as group 1 (Lucentis, n: 38) and group 2 (Avastin and /or Lucentis; n: 34). Fundus...

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PPV, Subretinal Injection of TPa and Intraocular Gas Tamponade for Thick Submacular Hemorrhage with ARMD

Advantages: To evaluate the safety and efficacy of pars plana vitrectomy, subretinal injection of tissue plasminogen activator (tPA) and intraocular gas tamponade for thick submacular hemorrhage caused by age-related macular degeneration. Methods: The authors reviewed the medical records of 16 consecutive patients who underwent pars plana vitrectomy, subretinal tPA (25ug/0.1ml) injection with 20% SF6 gas. The main outcome measures were...

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Management of Choroidal Neovascularisation in Best’s Disease

Purpose:   Review of the management of choroidal neovascularisation secondary to Best’s vitelliform macular dystrophy. Materials and methods: Eight eyes of 6 patients with Best’s disease complicated by choroidal neovascularization (CNV) were included. The visual acuity, angiographic and optical coherence tomography (OCT) findings were used to assess management outcome.  All patients presented with reduction in visual acuity.  Two...

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Submacular Surgery of High Pigment Epithelial Detachment in ARMD

Advantages: The purpose was to compare the effectiveness of intravitreal injection of ranibizumab and submacular surgery in patients with a subfoveal high pigment epithelial detachment (PED). Methods: The clinical trial included two groups of patients. Group 1 consisted of 11 patients (11 eyes), who received three initial intravitreal injections of ranibizumab. Group 2 consisted of 9 patients (9 eyes), who underwent intentional drainage...

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Comparison of the Incidence of Cardiovascular Morbidity in Patients Without and with Age-related Macular Degeneration

M Kowalska, J Ciszewska, K Wajs, D Kêcik (Warsaw, Poland) Advantages: The purpose of the study was to evaluate the incidence of cardiovascular diseases and risk factors in patients with dry and wet AMD. The control group consisted of patients with normal maculas. Methods: 242 patients: 156 pts with established diagnosis of AMD and a mean age of 70.8 +/- 12.1 years and 86 pts with normal appearing maculas and a mean age 69.8 +/- 7.2 years...

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Role of Anti-VEGF Drugs in Therapeutic Approach to Idiopathic Polypoidal Choroidal Vasculopathy

García Alonso Ana, Fonollá Gil Marta, Castro Navarro Joaquín, González Castaño Carmen (Oviedo, Spain) Advantages: Idiopathic Polypoidal Choroidal Vasculopathy (IPCV) has distinctive features among the spectrum of Age-related Macular Degeneration (AMD), as is poor response to anti-VEGF monotherapy. When macular involvement is present, Photodynamic Therapy (PDT) has provided the best outcomes. Nevertheless, persistent subretinal fluid...

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Expectant Attitude in Retinal Pigment Epithelium Detachment Associated to Hemochromatosis

F.J. Ascaso, P. Casas, C. Peiro, E. Nuñez, J. A. Cristóbal (Zaragoza, Spain) Advantages: Retinal pigment epithelium detachment (RPED) is a feature in many chorioretinal disorders. In other cases this condition occurs idiopathically. We report a case of idiopathic RPED in a patient with associated hemochromatosis. We decided to observe and not perform intravitreal antiangiogenic therapy because there was neither subretinal fluid nor a...

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Intravitreal Procrit in Eyes with Geographic Atrophy Secondary to ARMD

C Majcher (Salus), SH Sinclair (Drexel Univ School Med), W Li (Drexel Univ School Med), P Presti (Georgia Institute of Technology, Atlanta) Objective: Investigate erythropoietin intravitreal injections stabilization of central discriminant visual fields (CDVF) and GA progression in atrophic ARMD and correlate OCT findings with CDVF and patterns of GA progression. Methods: Retrospective pilot study of patients with GA AMD with fovea...

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Treatment of Submacular Hemorrhages from Macular Degeneration – One More Option

http://www.evrs.eu/medias/2010/congress/Hemorrhages.flv Ivan Tanev (Sofia, Bulgaria) Advantages: Sub-macular hemorrhage (SMH) is one of the most common complications of the neovascular age related macular degeneration (AMD). Eyes with large sub-retinal hemorrhages arising from exudative macular degeneration have a poor prognosis due to progressive fibrosis and organization of the sub-retinal clot.  Early removal of the sub-retinal blood...

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Anti-VEGF Monotherapy for Exudative ARMD Presenting with Concomitant Hemorrhages

http://www.evrs.eu/medias/2010/congress/Hemorrhages.flv Silvia Bopp, Andreas Schüler, Klaus Lucke (Bremen, Germany) Advantages:  To investigate the role of sub-retinal hemorrhages in exudative ARMD and investigate, if the hemorrhagic component influences the outcomes under continuous anti-VEGF therapy. Methods: Retrospective chart review of 30 patients presenting with exudative ARMD and concurrent sub-retinal hemorrhage of 2 disc...

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The Efficacy of Bevacizumab and Ranimizumab in Age-Related Macular Degeneration

Yong Sung You, Oh Kwon (Seoul, South Korea) Purpose: To compare the efficacy of Avastina and Lucentis in Neovascular AMD of Korean in South Korea. Materials and Methods: Retrospective, comparative study by reviewing the medical records of patients with wet AMD who were treated with anti-VEGF and followed up more than 6 months from January 2007 to November 2009. Results: 105 eyes (105 patients) were included. Avastin was injected in 32 eyes...

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Intravitreal Injection of Tissue Plasminogen Activator (TPA) and Gas C3F8 for the Management of Large Submacular Hemorrhage

Evangelia Papavasileiou, S. Liazos, Timothy Jackson (London, UK) Advantages: To describe the safety and efficacy of intravitreal TPA and C3F8 for the management of extensive sub macular hemorrhages (SMH), associated with AMD related choroidal neovascularisation (CNV) or Idiopathic Polypoidal Choroidal Vasculopathy (IPCV). Methods: Consecutive case series of 7 patients, presenting with acute SMH from neovascular AMD (N = 5) and IPCV (N =...

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Risk Factors for Recurrent Submacular Hemorrhage in Neovascular, Age-Related Macular Degeneration

June-Gone Kim, Sung Jae Yang, Jong Uk Hwang, Soo Geun Joe, Joo Yong Lee (Seoul, South Korea) Advantages: To describe the clinical characteristics and risk factors of recurrent, submacular hemorrhage in AMD. Methods: We reviewed the medical records of the neovascular AMD patients showing submacular hemorrhage at their onset. The required minimum follow-up period was 24 months, and any newly developed, submacular hemorrhage larger than one...

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Intravitreal Ranibizumab Combined with Verteporfin Photodynamic Therapy for Treating Polypoidal Choroidal Vasculopathy

Jung Yeul Kim (Daejeon, South Korea) Purpose: To evaluate the efficacy of intravitreal ranibizumab (Lucentis) with verteporfin photodynamic therapy (PDT) for patients with polypoidal choroidal vasculopathy (PCV). Patients and Methods: Seventeen eyes of 17 patients with symptomatic PCV who received three monthly intravitreal ranibizumab injections with PDT were retrospectively reviewed. The follow-up period lasted over 6 months after...

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Intravitreal Bevacizumab in Age-Related Macular Degeneration as a Rescue Therapy: Two-Year Results

Montserrat González-Sastre, Ignasi Jurgens, Rosa Sust-Ferrer (Barcelona, Spain) Purpose: To report the 2-year visual and anatomical outcomes in patients treated with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD) in patients who failed after photodynamic therapy (PDT) or were not eligible to that treatment. Methods: Prospective, nonrandomized, open-label study of 114 eyes of 88 patients with AMD. We...

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Intravitreal Ranibizumab for Neovascular Age-Related Macular Degeneration

Ebru Demet Aygit, Çigdem Altan, Hülya Güngel (Istanbul, Turkey) Advantages: This study reports clinical outcomes of intravitreal Ranibizumab treatment for choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) and to identify predictive factors that may influence visual acuity (VA) outcomes. Methods: Thirty-one patients (32 eyes) with CNV were followed up at least 6 months after intravitreal injection (0,5 mg)...

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Intravitreal Injection of Bevacizumab for Treatment of Subfoveal and Juxtafoveal Choroidal Neovascularization Associated with Pathologic Myopia: 2-Year Follow-Up

http://www.evrs.eu/medias/2010/congress/Non-Age-Related-Macular-Degeneration-Nor-Diabetes-Neovascularization.flv Barbara Parolini, Grazia Pertile (Verona, Italy) Advantages: The results of our study would advise an on-demand intravitreal injection of bevacizumab (IVB) for juxtafoveal and a monthly scheme for subfoveal myopic choroidal neovascularization (CNV). Methods: We retrospectively analyzed the charts of 45 patients with myopic CNV...

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Long-Term Effects of Intravitreal Bevacizumab (Avastin) in the Treatment of Choroidal Neovascular Membranes Due to Pathologic Myopia

http://www.evrs.eu/medias/2010/congress/Non-Age-Related-Macular-Degeneration-Nor-Diabetes-Neovascularization.flv Andriy Sergienko, Lyubomyr Lytvynchuk (Kyiv, Ukraine) Advantages: Intravitreal bevacizumab (Avastin) is a new and safe surgical treatment for choroidal neovascularization due pathologic myopia (myopic CNV). It allows controlling CNV activity and does not lead to development of foveal chorioretinal atrophy. In some cases, it...

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Surgical Approach to Peripheral Exudative Hemorrhagic Chorioretinopathy (PEHCR) with Macular Detachment

http://www.evrs.eu/medias/2010/congress/Non-Age-Related-Macular-Degeneration-Nor-Diabetes-Neovascularization.flv Alexandra Brix, Klaus Lucke (Bremen, Germany) Advantages: To describe PEHCR, a not so rare condition in the elderly. It is often only an accidental finding without functional or therapeutic consequences. There is surprisingly little literature on the condition which has been given a variety of names such as for instance...

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Age-Related Peripheral Degeneration

http://www.evrs.eu/medias/2010/congress/Non-Age-Related-Macular-Degeneration-Nor-Diabetes-Neovascularization.flv Ivan Fiser (Prague, Czech Republic) Advantages: Peripheral choroidal neovascularization (CNV) is not a rare condition in patients in the age group of Age Related Macular Degeneration (ARMD). Extramacular CNV can be far away from the macula, although the clinical appearance of the posterior pole may mimic the classic exudative...

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Peripheral Exudative Hemorrhagic Chorioretinopathy: Therapeutic Options

http://www.evrs.eu/medias/2010/congress/Non-Age-Related-Macular-Degeneration-Nor-Diabetes-Neovascularization.flv Grazia Pertile, Barbara Parolini, Matteo Cereda (Negrar, Italy) Advantages: Peripheral exudative hemorrhagic chorioretinopathy is a quite infrequent disease that can seriously threat visual function, especially in the case of bilateral presentation. We have to cope with massive exudation and/or large pigment epithelium...

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