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Effectiveness of Local Subretinal Injection of Xenogenic Stem Cells Labelled by Magnetic Particles

Iurii Belyi_SCIENTIFIC POSTER 2015_2 Purpose: To develop a technique for local subretinal injection of xenogeneic stem cells labeled with magnetic particles and to prove experimentally its effectiveness. Material and methods: We used a line of stem cells HEK-293 GFP, labeled with magnetic particles. The study was made on 84 eyes of 42 chinchilla rabbits 6 months of age, the weight were from 2.5 to 3.5 kg. All right eyes were experimental...

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Role of Inflammatory Process in Membrane Formation Different Retinal Diseases Histapathological Study

Purpose: To explain the Role of inflammatory process in membrane formation different retinal diseases using histopathological study. Material & methods: Histopathological study of membranes in deferent retinal disease from 80 cases taken during pars plana vitrectomy in different cases. 40 cases of advanced diabetic retinopathy with tractional retinal detachment. 20 cases of retinal detachment. 10 cases of membrane under silicon. 5...

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Is Process of Epiretinal Membrane Biopsy Analysis Easy?

Purpose : To show the process of epiretinal membrane biopsy analysis. Methods: Five cases of different retinal disease that have epiretinal membrane formation, during pars plana vitreoctomy membrane peeled and placed in a tube with 10% formalin then sent to histopathology laboratory for preparation and analysis. Results: It’s not easy to work with epiretinal membrane because it’s very tiny fragments measuring about 0.2-0.3 cm...

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What is an ERM; How Could ILM Peeling Work?

An idiopathic epiretinal membrane is a syndrome associating a macular oedema, a reactive astrocytic gliosis and an adherent plaque of posterior hyaloid. The astrocytic proliferation enters the hyaloid fibres so that the typical reflection can appear. When there is no adherent plaque of hyaloid, an aspect of pure oedema is observed. ILM removal has two functions: It removes the hyaloid fibres entirely and therefore treats the retraction...

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Quantitative Determination and Comparison of Intravitreal Cytokines in PDR and RVO

Purpose: To determine inflammatory and angiogenetic cytokine levels from undiluted vitreous of patients with diabetic retinopathy (DRP), retinal vein occlusion (RVO) and exsudative age-related macular degeneration (ARMD) and compare them with clinical and anatomic changes. Methods: 187 patients (median age 67.0 years, 101 male) underwent a single-site 23-gauge core vitrectomy for a centred intravitreal application of a combined therapy...

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Pathological Findings in Macular Edema

The retina and particularly the macula react spontaneously to different pathological conditions. In case of retinal detachment, as in case of any injury, there is a stimulation of EGF-R (epidermal growth factor receptor), which regulates the gliosis, the tissue homeostasis, the injury response, the stem cell proliferation, the angiogenesis and the anti-apoptotic factor.  Under EGF-R stimulation, the microglia stimulate the Müller cells,...

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